Searchable abstracts of presentations at key conferences in endocrinology

ea0015p150 | Diabetes, metabolism and cardiovascular | SFEBES2008

Activation of the unfolded protein response pathway in the skeletal muscle of hexose-6-phosphate dehydrogenase knockout mice induces a severe myopathy

Lavery Gareth , Bujalska Iwona , Turan Nil , Falciani Francesco , Walker Elizabeth , Stewart Paul

Hexose-6-phosphate dehydrogenase (H6PD) is a sarcoplasmic reticulum (SR) resident enzyme that metabolizes glucose-6-phosphate and generates NADPH that drives the activation of glucocorticoids by 11β-hydroxysteorid dehydrogenase type 1. H6PD KO mice exhibit improved skeletal muscle insulin sensitivity increased glucose uptake and glycogen storage. However, H6PD KO mice also develop a myopathy with switching from Type II to Type I fibers. Affected muscles have apparently no...