Searchable abstracts of presentations at key conferences in endocrinology

ea0078oc3.2 | Oral Communications 3 | BSPED2021

Variable responses to sulfonylurea treatment in siblings from the same family with monogenic diabetes due to HNF1A mutation

Franklin Natasha , Hawton Katherine , Giri Dinesh

Background: Maturity onset diabetes of the young (MODY) is characterized by autosomal dominant inheritance, onset before 25 years of age, absence of β-cell autoimmunity, and sustained pancreatic β-cell function. HNF1A mutations account for 70% of MODY cases. Patients with HNF1A MODY are sensitive to sulfonylureas (SU) and can maintain optimal glycaemic control with SU rather than insulin. We describe 2 siblings from the same family with HNF1A</e...