Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep137 | Calcium and Vitamin D metabolism | ECE2016

Mass Spectrometry coupled with liquid chromatography (HPLC-MS-MS) levels of 25-hydroxy vitamin D (25OHVitD) are associated with prognostic markers of Heart Failure

Saponaro Federica , Saba Alessandro , Frascarelli Sabina , Marcocci Claudio , Cetani Filomena , Passino Claudio , Zucchi Riccardo

Introduction and aims: Heart failure (HF) is a health problem with poor prognosis, despite many treatments available. Vitamin D is the pre-hormone of the active calcitriol (1,25(OH)2D3). It is involved in bone homeostasis, but recent studies suggest extraskeletal functions, including pleiotropic effects on cardiovascular system and a relationship between low levels of 25OHvitamin D and worse HF prognosis. The aims of the study were: 1) to define 25OH-D levels in the HF populat...

ea0070aep857 | Thyroid | ECE2020

Association with 3-iodothyronamine improves the effect of levothyroxine on neurocognitive symptoms in a mouse model of adult-onset hypothyroidism

Rutigliano Grazia , Frascarelli Sabina , Borsò Marco , Bandini Lavinia , Zucchi Riccardo

Adult-onset hypothyroidism is related to anxiety, depression, and impaired neurocognition. Guidelines from all professional societies recommend levothyroxine (LT4) monotherapy as the treatment of choice. However, ~15% hypothyroid patients do not achieve a satisfactory functional level despite TSH within the reference range. The beneficial effects of combining LT4 and liothyronine (LT3) to improve neuropsychiatric functions remains unclear. Recently, 3-iodothyronamine (T1A...

ea0032p744 | Obesity | ECE2013

Modulation of gene expression by 3-iodothyronamine: evidence of a lipolytic pattern

Mariotti Veronica , Ioffrida Caterina , Melissari Erika , Russo Manuela Di , Frascarelli Sabina , Pellegrini Silvia , Zucchi Riccardo

3-Iodothyronamine (T1AM) is a recently discovered compound which can be regarded as a novel hormone, since it is an endogenous relative of thyroid hormone with systemic distribution, which does not interact with thyroid hormone receptors, but rather with specific G protein-coupled receptors. T1AM has been reported to modulate energy metabolism, and in rodents chronic T1AM treatment has been associated with lipolysis and decreased body weight. T...

ea0056p234 | Calcium & Vitamin D metabolism | ECE2018

Quantification of serum 25-hydroxyvitamin D: a comparison between competitive chemiluminescence immunoassay and mass spectrometry coupled to high performances liquid chromatography

Saponaro Federica , Frascarelli Sabina , Saba Alessandro , Prontera Concetta , Clerico Aldo , Scalese Marco , Passino Claudio , Marcocci Claudio , Zucchi Riccardo

Serum 25-hydroxy-vitamin D (25OHD) is considered the most reliable marker of vitamin D status. Adequate levels 25OHD of are necessary for pleiotropic effects of vitamin D, either skeletal or extra-skeletal. Traditional assays based on immunoassay often show an unsatisfactory accuracy and sensibility. A valuable alternative is Tandem Mass Spectrometry coupled to High Performances Liquid Chromatography (HPLC-MS-MS), that offers a good quantification accuracy, as the contribution...

ea0081p298 | Calcium and Bone | ECE2022

Evaluation of pth deprivation effects on spatial memory in a rat model of chronic post-surgical Hypoparathyroidism

Saponaro Federica , Ronca Francesca , Dettori Cristina , Frascarelli Sabina , Di Buono Giulia , Giacomelli Silvia , Chiellini Grazia , Scalese Marco , Cetani Filomena , Marcocci Claudio , Zucchi Riccardo

Introduction: Hypoparathyroidism (HypoPT) is a rare endocrine disease which is characterized by hypocalcaemia and undetectable or inappropriately low serum parathyroid hormone (PTH). Post-surgical HypoPT (PS-HypoPT) is the most common cause, caused by accidental parathyroid removal/injury during neck surgery. Conventional therapy with calcium and vitamin D analogues does not restore calcium homeostasis and patients with chronic PS-HypoPT complain with several complications. Fr...

ea0084op-08-38 | Oral Session 8: Basic 2 | ETA2022

Brain effects of combined levothyroxine (T4) and 3-iodothyronamine (T1AM) replacement therapy in a murine model of hypothyroidism

Bertolini Andrea , Ricardi Caterina , Maria Grittani Nicoletta , Ippolito Chiara , Moscato Stefania , Mattii Letizia , Frascarelli Sabina , Chiellini Grazia , Saba Alessandro , Zucchi Riccardo , Rutigliano Grazia

Adult-onset hypothyroidism is associated with cognitive dysfunction, and a significant fraction of hypothyroid patients still shows persistent disturbances despite standard T4 replacement therapy. Experimental results showed that tissue levels of T4 metabolites, particularly T1AM, are decreased in hypothyroidism and remain low after T4 replacement. Thyroid hormones are important for the promotion of neurogenesis and neuron migration to different areas of the cerebral cortex, i...