Endocrine Abstracts

Low birth weight is associated with adult disorders characterised by insulin resistance such as type 2 diabetes, hypertension, dyslipidaemia and coronary heart disease. However the mechanism of this established association is still uncertain and controversial. For the past decade research has principally focused on the role of the intra-uterine environment. It has been proposed that under nutrition in utero results in a permanent re-programming of the fetal metabolism. Genetic...

Introduction: There remains considerable debate over combination T4/T3 therapy for thyroid hormone replacement. Whilst large randomised-controlled studies have failed to show benefit over T4 only, there remain patients who feel better on the combination. Animal studies suggest that up to 80% of intracellular T3 in the brain is derived from circulating T4 by local deiodination. We hypothesized that in patients on thyroxine ...

Type 2 diabetes (T2DM) has emerged in youth, disproportionately affecting ethnic minorities. Maturity Onset Diabetes of the Young (MODY) has been reported in exclusively white UK children. We report the first UK Asian children with MODY, highlighting differences from T2DM.Child 1 is a slim (BMI SDS−0.14) female of Indian descent without acanthosis nigricans (AN). She presented aged 12 years with polydipsia and polyuria (HbA1c 8.6%). Hypoglycaemia w...