Searchable abstracts of presentations at key conferences in endocrinology

ea0028p303 | Steroids | SFEBES2012

Demonstration of blood pressure-independent diffuse cardiac fibrosis in Primary Aldosteronism- a cardiac MRI study

Freel Ellen , Mark Patrick , Weir Robin , McQuarrie Emily , Allan Karen , Dargie Henry , Jardine Alan , Davies Eleanor , Connell John

Background: Primary Aldosteronism (PA) is common and associates with excess cardiovascular morbidity independent of blood pressure. Animal and in vitro studies have demonstrated that exposure to aldosterone and sodium leads to cardiac fibrosis and hypertrophy and this may, partly, be mediated by inflammation and oxidative stress. We aimed to clarify the effects of aldosterone excess on myocardial structure and composition in humans using contrast-enhanced cardiac MRI as well a...