Searchable abstracts of presentations at key conferences in endocrinology

ea0037oc8.2 | Endocrine tumours | ECE2015

Role of microenvironment on neuroblastoma SK-N-AS SDHB silenced cell metabolism and function

Rapizzi Elena , Fucci Rossella , Giannoni Elisa , Canu Letizia , Richter Susan , Cirri Paolo , Mannelli Massimo

Solid tumours are very complex tissues comprising not only cancer cells, but also non-malignant stromal cells such as endothelial cells, fibroblasts, immune cells and extracellular matrix, forming the so called tumour microenvironment. In the last few years, it has become more and more evident the pivotal role of the tumour microenvironment in modulating cancer progression and metastasis. Tumour microenvironment has thus become a potential therapeutic target. To obtain an expe...

ea0032p67 | Adrenal Medulla | ECE2013

Succinate dehydrogenase subunit B mutations modify human neuroblastoma cell metabolism and proliferation

Zampetti Benedetta , Rapizzi Elena , Ercolino Tonino , Fucci Rossella , Felici Roberta , Guasti Daniele , Giache Valentino , Bani Daniele , Chiarugi Alberto , Mannelli Massimo

Paragangliomas (PGLs) are rare neuroendocrine tumors. About 30–40% of these tumors are mutated in different susceptibility genes, including those encoding the different subunits of the succinate dehydrogenase, a complex involved both in the tricarboxylic acid cycle and in the oxygen transport chain. The aim of this project was to investigate whether SDHB mutations may account for alterations in cell metabolism and functions. Since PGL cell lines are not available, we used...