Searchable abstracts of presentations at key conferences in endocrinology

ea0031p382 | Thyroid | SFEBES2013

An unusual association with autoimmune hypothyroidism

Overend Louise , Furlong Niall , McNulty Steven

Background: Untreated hypothyroidism may be associated with cutaneous signs including coarse, dry skin and hair loss. Myxoedema (also known as thyroid dermopathy) is usually associated with Graves’ thyrotoxicosis but has been reported in patients with hypothyroidism. We describe an unusual skin disorder in a patient with autoimmune hypothyroidism, initially misdiagnosed as myxoedema.Case: A 41-year-old female with an extensive medical history includ...

ea0025p234 | Pituitary | SFEBES2011

The risk of cardiac valvulopathy in cabergoline-treated endocrine patients in a district general hospital

Balaguruswamy Saravanan , Lewis Natalie , McNulty Sid , Furlong Niall

Aim: Over the last decade, cardiac valvular fibrosis has been associated with the use of high dose (ergot-derived) dopamine agonist therapy in Parkinson’s disease. Although the risk in endocrine patients appears significantly lower, routine echocardiographic monitoring is now recommended. This study evaluated the incidence of significant cardiac valvulopathy in endocrine patients treated with cabergoline in a District General Hospital Population, and compliance with MHRA ...

ea0062p50 | Poster Presentations | EU2019

Nature’s price for Cushing’s disease: A blind eye and a hole in the (pituitary) Middle

Sullivan Heather , Westall Sam , McNulty Sid , Furlong Niall , Gilkes Catherine , Daousi Christina , Narayanan Prakash

Case history: A 61 year old male with a background of diabetes mellitus Type 2 and congestive cardiac failure (CCF) was diagnosed with Cushing’s disease in 2014 following identification of severe osteoporosis through investigations for non-traumatic vertebral fractures causing paraplegia.Investigations: He had high ACTH and cortisol levels which failed to suppress on low and high dose dexamethasone suppression tests, hypogonadotrophic hypogonadism a...

ea0034p79 | Clinical practice/governance and case reports | SFEBES2014

Patient feedback on receiving copies of clinic correspondence

Narayanan Ram Prakash , Chiran Preeti , McNulty Steven J , Shankar Upendram Srinivas , Furlong Niall

Background and aim: The Department of Health and NHS Plan both recognise that sending patients copies of clinic correspondence can help inform and empower them. At St Helens and Knowsley Teaching Hospitals NHS Trust, Endocrinology Clinic we routinely provide patients with a copy of the clinic correspondence sent to their General Practitioner (GP), unless patients specifically opt out. Our aim was to evaluate patients’ views on receiving such copy correspondence following ...

ea0034p388 | Thyroid | SFEBES2014

A rare cause of clinical hypothyroidism: thyroid hormone resistance

Narayanan Ram Prakash , Chiran Preeti , Al-Jubouri Mohammad , McNulty Steven , Furlong Niall

Thyroid hormone resistance is a rare but recognised cause of clinical hypothyroidism. We explain a case of clinical hypothyroidism that was associated with thyroid hormone resistance.A 48-year Caucasian female with no known personal or family endocrine history was referred with a 12-month-history of weight gain and increased tiredness. Past history included depression and osteoarthritis, with regular medications being NSAIDs and amitryptiline. There was ...

ea0028p5 | Bone | SFEBES2012

Bone mineral density in a clinic-based cohort of hypogonadal men

McLorinan Joanna , Overend Louise , Mason Ryan , Mohamed Yunus Ajmal , McNulty Steven , Furlong Niall , Srinivas-Shankar Upendram

Background: Male hypogonadism is associated with reduction in bone mineral density (BMD). This study aimed to determine the epidemiology of low BMD in a clinic-based cohort of hypogonadal men.Methods: This was a retrospective, cross-sectional observational study of 152 patients (≥18 years with testosterone(T) ≤11 nmol/L) who were consequently reviewed in an endocrine clinic. Data was extracted from electronic patient records and included base...

ea0028p293 | Reproduction | SFEBES2012

Prevalence of modifiable risk factors among a clinic-based cohort of secondary hypogonadal men

Mclorinan Joanna , Overend Louise , Mohamed Yunus Ajmal , Mason Ryan , McNulty Steven , Furlong Niall , Srinivas-Shankar Upendram

Background: Male hypogonadism is commonly caused by hypothalamo-pituitary testicular disease. The effect of modifiable risk factors (obesity, alcohol, smoking, prescribed medications and recreational drugs) on secondary hypogonadism in a clinic-based cohort is unclear. The aim of this study was to ascertain the prevalence and effects of modifiable risk factors on secondary hypogonadism.Method: This was a retrospective, cross-sectional observational study...

ea0025p305 | Steroids | SFEBES2011

Is there a threshold morning cortisol level at which to perform the short synacthen test?

Bujawansa Sumudu , Kunasegaran Shalini , McNulty Steve , Hardy Kevin , Al-jabouri Mohammad , Furlong Niall , Srinivas-Shankar Upendram

Introduction: Short synacthen test (SST) is of value in assessing the adequacy of hypothalamic–pituitary–adrenal axis (HPA). Although it is extensively used, it is unclear at what morning cortisol concentration one should consider performing the SST.Methods: Retrospective observational study of consecutively performed SST (250 μg) between January 2009 and March 2010. Plasma cortisol was measured by enzyme immunoassay (Siemens Advia, Siemen...

ea0021p69 | Clinical practice/governance and case reports | SFEBES2009

Androgen-producing tumour in a transposed ovary: a diagnostic difficulty

Chandrasekara Wasala M H S , Balaguruswamy Saravanan , McNulty Sid , Furlong Niall

Case report: A 52-year-old woman presented with an 11-month history of increasing hirsutism and deepening voice. She had a past history of total abdominal hysterectomy (ovaries preserved) with adjuvant chemotherapy and radiotherapy for cervical carcinoma. She was on no medication. Examination revealed evidence of virilisation with no other abnormality.Investigations: Total testosterone=10.7 nmol/l (<2.9).FSH=31.7 U/l (37–1...

ea0021p84 | Clinical practice/governance and case reports | SFEBES2009

Recurrent pregnancy-related hypokalaemia associated with Gitelman's syndrome

Balaguruswamy Saravanan , Chandrasekara W M H S , Rao Sandhya , Furlong Niall , Abdalla Tarig

Gitelman’s syndrome (GS) is a rare autosomal recessive renal tubular disorder caused by defects of thiazide sensitive Na-Cl co-transporter due to mutations of the SLC12A3 gene.We report a case of a 23-year-old woman, who presented with excessive tiredness in her second pregnancy. She had a past history of hypokalaemia in a previous pregnancy (attributed to ‘vomiting’), which required multiple admissions for i.v. potassium replacement despi...