Searchable abstracts of presentations at key conferences in endocrinology

ea0016p676 | Steroid receptors | ECE2008

Glucocorticoid receptor gene polymorphisms in patients with Cushing's disease and adrenal Cushing's syndrome

Szappanos Agnes , Patocs Attila , Toke Judit , Sereg Marta , Futo Laszlo , Kende Zoltan , Varga Ibolya , Glaz Edit , Racz Karoly , Toth Miklos

Introduction: The hypothalamic┬ľpituitary┬ľadrenal axis setpoint and the glucocorticoid sensitivity in various tissues are at least partly genetically determined. The glucocorticoid receptor (GR) gene polymorphisms may have an impact on the development and/or the variability of clinical manifestations of endogenous hypercortisolism, however their role has not been investigated in patients with endogenous hypercortisolism.Methods: We investigated ...