Searchable abstracts of presentations at key conferences in endocrinology

ea0011s34 | Clinical lessons from novel aspects of G protein-coupled receptors signalling | ECE2006

How the pattern of GPCR co-expression can regulate function

Milligan G , Pediani J , Ellis J

The pharmacology and function of G protein-coupled receptors (GPCRs) is frequently studied following expression of a single receptor in heterologous cell lines. However, many GPCRs are co-expressed. We wished to investigate how expression of pairs of receptors might modulate their function. Using a Human Embryonic Kidney 293 cell line in which the CB1 cannabinoid receptor was expressed constitutively and in which varying levels of expression of the orexin-1 receptor could be i...