Endocrine Abstracts

Objective: To compare metabolic characteristics of women with different phenotype of polycystic ovary syndrome (PCOS) based on Rotterdam criteria.Materials and methods: One thousand one hundred women with PCOS, aged 17–40, were recruited. The patients were divided into four subgroups according to the phenotype of PCOS defined by Rotterdam criteria: (A): oligo- and/or anovulation (Oligo), hyperandrogenism (HA), polycystic ovaries (PCO); (B): oligo+ H...

Introduction: We present 3 cases of the same severe electrolyte imbalance presenting with acute neurological symptoms.Case descriptions: Case A, a 48 year old lady with severe CREST syndrome presented with prolonged vomiting and diarrhoea. Initial investigations showed: Sodium 141 mmol/l, Potassium 3.2 mmol/l, Creatinine 53 mmol/l, Glucose 4.3 mmol/l, Haemoglobin 13.9 g/dl, Albumin 38 g/l. 2 days after admission she developed seizures. Case B, a 75 year ...

BackgroundIt has been shown that diets high in cis-MUFA and high-antioxidant diets are beneficial in type 2 diabetes (Garg 1998; Ros 2003; Franz et al. 2002). The aim of our study was to assess compliance with current dietary recommendations (Diabetes UK 2003) with particular emphasis on these nutrients.MethodsEthical approval was obtained to use a food diary and lifestyle questionnaire. 120 Cau...

Objective: Interindividual variation in glucocorticoid sensitivity can be partly explained by polymorphisms in the GC receptor gene. The most frequent polymorphisms of the GR gene (N363S and BclI) are associated with increased BMI, less lean mass, higher cholesterol and insulin levels. In the present study we investigated the role of the N363S and the BclI polymorphisms in patients with adrenal disease to evaluate their prevalence and the possible clinic and hormone correlatio...

Background: Inflammation is involved in the pathogenesis of complications of type 1 diabetes (T1DM). We aimed to assess the differences in the markers of endotoxaemia and faecal calprotectin in patients with T1D different status of diabetic kidney disease (DKD).Methods: 31 generally healthy adults (control) and 74 patients with T1DM and were included. Of the latter, 13 had DKD (defined as microalbuminuria, macroalbuminuria, estimated glomerular filtratio...

Glucose metabolism was investigated in 65 patients with Cushing’s syndrome (CS), 19 with cortisol-secreting adrenal adenoma (mean age 47.2±4.9), 40 with ACTH secreting pituitary adenoma (mean age 41.4±12.48), 4 with cortisol secreting adrenal cancer (mean age 63.0±8.4) and 2 patients with ectopic ACTH secretion (38.7±11.9).Eleven patients (17%) were diagnosed as diabetic after abnormal fasting glucose levels (>126 mg/dl). Whi...

Androgens play an important part in follicular development, sexual behavior, maintenance of skeletal homeostasis, normal affect and cognitive function. The negative influence of androgen deficiency is widely discussed in postmenopausal women. However, there is a cohort of young women with gonadal steroid deficit caused by the disorders of central regulation. It is well known that these patients are in lack of estrogens however their androgen status is not detailed.<p class...

Kisspeptin-54 is a neuropeptide encoded by the Kiss-1 gene with an important role in the regulation of reproduction and puberty. Acute peripheral or intra-hypothalamic administration of kisspeptin-54 potently stimulates the hypothalamo-pituitary-gonadal (HPG) axis via hypothalamic gonadotrophin releasing hormone (GnRH) neurons. However, the effects of chronic continuous kisspeptin administration are poorly characterised. Our studies investigated the effects of chronic, continu...

Introduction: Fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) is an innovative method for the detection of primary tumours or metastases of thyroid cancer; however, recurrence or metastases of medullary thyroid carcinoma (MTC) are still difficult to detect.Aim: The objective of this study was to evaluate the clinical use of 18F-FDG PET in patients with MTC.Patients and methods: We enr...

The kisspeptins are KiSS-1 gene-derived peptides which signal through the G protein coupled receptor 54 (GPR54), and have recently been shown to be critical regulators of reproduction. Acute intracerebroventricular (ICV) or peripheral administration of kisspeptin to rodents and primates, and peripheral administration to humans, stimulates the hypothalamic-pituitary gonadal (HPG) axis. This effect is thought to be mediated via the hypothalamic gonadotrophin-releasing hormone (G...