Searchable abstracts of presentations at key conferences in endocrinology

ea0063p549 | Diabetes, Obesity and Metabolism 2 | ECE2019

PRIMAVERA study: sibutramine therapy safety monitoring in patients with obesity

Troshina Ekaterina , Mazurina Natalya , Galieva Marina , Melnichenko Galina , Dedov Ivan

Objective: The aim of the study was to assess the effectiveness and safety of long-term sibutramine therapy in routine clinical practice.Materials and methods: In total, 98 774 patients (82.3% women, 17.7% men), from 142 cities of the Russian Federation were enrolled in the PRIMAVERA program. The mean age of the patients was 39.39±10.38 years, the mean body weight was 99.1±14.28 kg, and the mean BMI was 35.7±4.41 kg/m2. Physicia...

ea0063p553 | Diabetes, Obesity and Metabolism 2 | ECE2019

Polymorphisms of genes GNB3, SERT, NET, TPH2 and results of obesity treatment with sibutramine

Mazurina Natalya , Galieva Marina , Troshina Ekaterina , Volynkina Anna , Artyushin Andrey , Pavlova Anastasiya , Logvinova Oksana

Introduction: Results obtained from PRIMAVERA study have demonstrated that 7.5% of obese individuals does not respond to sibutramine therapy. The aim of the study was to evaluate if GNB3, SERT, NET, TPH2 genes polymorphisms are associated with the results of obesity treatment with sibutramine.Methods: 69810 obese patients took sibutramine for at least 3 months. According to the results of 3 months therapy, we formed two groups of patients: 1) &#...

ea0070aep471 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Circulating steroid hormones and BMI in men

Mazurina Natalya , Ershova Ekaterina , Komshilova Ksenya , Galieva Marina , Seniushkina Evgeniya , Ioutsi Vitaly , Troshina Ekaterina

Introduction: Previous studies reported significant associations of steroid hormones with anthropometric parameters including body-mass-index (BMI) and waist circumference, as well as with some metabolic parameters such as triglycerides.Methods: 48 reproductive age males (age 18–49) were included in the study (27 obese individuals, 12 persons with excess body weight, 9 normal weight controls). We have examined the association between circulating st...