Searchable abstracts of presentations at key conferences in endocrinology

ea0035oc9.2 | Reproduction | ECE2014

Tadalafil ameliorates metabolic syndrome-induced alterations in visceral adipose tissue and liver: an experimental study in the rabbit

Vignozzi Linda , Filippi Sandra , Cellai Ilaria , Comeglio Paolo , Maneschi Elena , Galli Andrea , Maggi Mario

Visceral adipose tissue (VAT) dysfunction is closely associated with the rising incidence of cardiovascular diseases (CVD) and type 2 diabetes mellitus. Two distinct types of adipose tissue, white (WAT) and brown (BAT), are present in mammals. Development of ‘brown-like’ adipocytes within white adipose tissue has potential antiobesity and insulin-sensitizing effects. Genetic manipulation of cGMP formation suggests a new role for this pathway in preadipocytes commitme...

ea0063p604 | Diabetes, Obesity and Metabolism 2 | ECE2019

The effects of testosterone treatment on fat tissue dysfunction and nonalcoholic fatty liver disease in obese men undergoing bariatric surgery

Maseroli Elisa , Corno Chiara , Comeglio Paolo , Cellai Ilaria , Filippi Sandra , Mello Tommaso , Galli Andrea , Facchiano Enrico , Beltrame Benedetta , Lucchese Marcello , Rastrelli Giulia , Maggi Mario , Vignozzi Linda

Objective: Substitution treatment of hypogonadism in clinical and experimental models has shown beneficial effects on insulin sensitivity and accumulation of visceral and liver fat. Aim of the study was to analyze the effects of testosterone replacement therapy on benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS) clinical parameters, adipose tissue dysfunction and nonalcoholic fatty liver disease (NAFLD) in obese patients candidates for bariatric surgery.</p...

ea0035p696 | Male reproduction | ECE2014

Nonalcoholic steatohepatitis as a novel player in metabolic syndrome-induced erectile dysfunction: an experimental study in the rabbit

Vignozzi Linda , Filippi Sandra , Comeglio Paolo , Cellai Ilaria , Rastrelli Giulia , Morelli Annamaria , Galli Andrea , Saad Farid , Mannucci Edoardo , Adorini Luciano , Maggi Mario

A pathogenic link between erectile dysfunction (ED) and metabolic syndrome (MetS) is now well established. Nonalcoholic steatohepatitis (NASH), the hepatic hallmark of MetS, is regarded as an active player in the pathogenesis of MetS-associated cardiovascular disease (CVD). This study was aimed at evaluating the relationship between MetS-induced NASH and penile dysfunction. We used a non-genomic, high fat diet (HFD)-induced, rabbit model of MetS, and treated HFD rabbits with t...

ea0022p722 | Signal transduction | ECE2010

Peroxisome-proliferator-activated receptor gamma is required for modulating endothelial inflammatory response through a novel nongenomic mechanism

Cantini Giulia , Lombardi Adriana , Borgogni Elisa , Francalanci Michela , Ceni Elisabetta , Gelmini Stefania , Poli Giada , Galli Andrea , Serio Mario , Forti Gianni , Luconi Michaela

Besides their well-known anti-diabetic effects, the peroxisome proliferator-activated receptor γ (PPARγ) thiazolidinedione ligands (TZD) have been suggested to also display anti-inflammatory properties. The receptor role in mediating such effects is far from being elucidated. Here, we demonstrate that PPARγ is necessary for TZD to interfere with TNFα and IFNγ inflammatory activity in human endothelial cells. Different PPARγ ligands similarly inhib...

ea0014p13 | (1) | ECE2007

Rosiglitazone interferes with the inflammatory response induced in human endothelial cells by TNFalpha and IFNgamma through a new mechanism involving extracellular signal-regulated kinases (ERKs)

Lombardi Adriana , Piscitelli Elisabetta , Francalanci Michela , Mello Tommaso , Santarlasci Veronica , Gelmini Stefania , Cantini Giulia , Galli Andrea , Cosmi Lorenzo , Annunziato Francesco , Forti Gianni , Serio Mario , Luconi Michaela

Microvascular endothelium is one of the main character and target involved in the inflammatory response. Upon specific activation, endothelial cells massively recruit Th1 IFNgamma secreting lymphocytes at the inflammatory site. In the present study, we investigate the intracellular signalling mediating TNFalpha (T) and IFNgamma (I) inflammatory response in a human endothelial cell line (HMEC-1) in vitro and the interfering effects of rosiglitazone (RGZ), a peroxisome pr...