Searchable abstracts of presentations at key conferences in endocrinology

ea0016p11 | Adrenal | ECE2008

Phosphodiesterase inhibitors and adrenal response to exercise-related stress

Sgro Paolo , Gallotta Maria Chiara , Emerenziani Gian Pietro , Fierro Valentina , Guidetti Laura , Baldari Carlo , Romanelli Francesco , Lenzi Andrea , Di Luigi Luigi

Worldwide numerous active individuals take phosphodiesterase type 5 inhibitors (PDE-5i), furthermore, to our knowledge, the effects of these drugs on hormone secretion has not been adequately investigated. In particular, considering that a) PDE-5i influence NO bioavailability, b) NO is one of the mediators of the hypothalamus┬ľpituitary┬ľadrenal (HPA) axis response to stress, and, c) physical exercise-related stress activate HPA axis, we investigated whether PDE-5i inf...