Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep980 | Pituitary - Clinical | ECE2017

Associated neoplasia in Romanian acromegalic patients

Silea Simona , Galoiu Simona , Dumitrascu Anda , Niculescu Dan , Baciu Ionela , Poiana Catalina

Introduction: Acromegaly has various complications that significantly alter patientsÂ’ lives, one of which is developing neoplasia, a subject of high interest in the scientific community during the last years but without any firm conclusions.Aim: The main objective of this paper was to verify if Romanian acromegalic patients are susceptible to developing neoplasia and what types of tumors are associated with acromegaly. Another purpose of the paper w...

ea0067gp12 | Poster Presentations | EYES2019

Long term evolution of a patient with metastatic neuroendocrine carcinoma of unknown primary site: A clinical puzzle for the endocrinologist

Mitru Natalia , Galoiu Simona , Poiana Catalina

Background: Carcinoid tumors are rare and slow growing malignancies derived from enterochromaffin cells. Two-thirds of carcinoid tumors arise in the gastrointestinal tract, and in 3% of these cases the primary site cannot be determined. Presenting symptoms depend on the location of the primary tumor may be nonspecific and in 13% of patients distant metastases are discovered on diagnosis.Case presentation: A 64 years old woman was admitted for diffuse abd...

ea0020p224 | Endocrine tumours and neoplasia | ECE2009

Lanreotide effects on glucose metabolism in evolutive acromegaly in remission during chemotherapy

Galoiu Simona , Purice Mariana , Hortopan Dan , Dumitrascu Anda , Coculescu Mihail

Lanreotide has long been used in the therapy of GH secreting pituitary adenomas and other somatostatin receptor positive neuroendocrine tumors.Aims: To determine the impact on glucose metabolism of the 6 months of lanreotide therapy, beside of the antisecretory and antiproliferative effects.Patients and methods: Seven patients with active acromegaly treated with lanreotide, admitted in the Department of Neuroendocrinology, Institut...

ea0090p37 | Calcium and Bone | ECE2023

Vertebral fractures in acromegaly

Sorohan Madalina , Baciu Ionela , Galoiu Simona , Caragheorgheopol Andra , Iordachescu Carmen , Poiana Catalina

Introduction: Acromegalic bone disease is characterized by an increased prevalence of fragility vertebral fractures (VFs). However, an effective, non-invasive and cost-efficient imaging technique that can diagnose early bone alterations in this category of patients is yet to found. The use of bone mineral density (BMD) is not as useful as in other causes of osteoporosis as excess GH leads to specific microarchitectural alteration of trabecular bone, which donÂ’t translate ...

ea0090ep652 | Endocrine-related Cancer | ECE2023

Different phenotype of familial RET mutation in 2 patients: Medullary thyroid carcinoma and Adrenal Paraganglioma

Naglabeala Laura , Milicescu Alexandra , Galoiu Simona , Braha Elena , Muresan Andrei , Ioachim Dumitru , Ghemigian Mircea , Poiana Catalina

Introduction: RET proto-oncogene is situated on chromosome 10 and encodes a tyrosine kinase receptor. A germline mutation of RET leads to the appearance of MEN 2 syndrome or familial medullary thyroid carcinoma (MTC). One of the most common germline mutation occurs in codon 634. Pheochromocytoma penetrance for codon 634 mutation was demonstrated to increase with age up to 88% by age 77 years.Aim: To present two familial cases of RET mutation illustrating...

ea0049ep1007 | Pituitary - Clinical | ECE2017

Residual tumour diameter may influence reduced survival in females with nonfunctioning pituitary macroadenomas

Galoiu Simona , Burcea Iulia , Silea Simona , Voicu Oana , Baciu Ionela , Dumitrascu Anda , Caragheorgheopol Andra , Poiana Catalina

Objective: Patients with pituitary macroadenomas and concomitant hypopituitarism have a reduced life expectancy due to various comorbidities.Aim: To investigate mortality in patients with non-functioning pituitary adenomas (NFAs) and independent prognostic factors influencing survival.Design: Retrospective cohort study in a tertiary neuroendocrine university department.Methods: A total of 364 patients (177F/1...

ea0059p203 | Thyroid | SFEBES2018

Characterization of thyroid nodules in acromegalic patients

Trifanescu Raluca , Galoiu Simona , Niculescu Dan , Baciu Ionela , Capatina Cristina , Radian Serban , Poiana Catalina

Background: Thyroid nodules were reported with high prevalence in acromegalic patients.Patients and methods: 63 acromegalic patients (16 males and 47 females), aged at diagnosis 43.6±12.7 years were retrospectively reviewed. Median duration of acromegaly was 8 years. 25 patients were residents in iodine deficient areas. GH, IGF1, TSH, FT4 were measured by chemiluminescence (Liaison). Thyroid ultrasound was performed. In suspected nodules,...

ea0037ep757 | Pituitary: clinical | ECE2015

Cure rates and survival in patients with acromegaly

Galoiu Simona , Suvoiala Andreea , Purice Mariana , Caragheorgheopol Andra , Trifanescu Raluca , Coculescu Mihail , Poiana Catalina

Introduction: An improvement of survival in patients with acromegaly was claimed in the last years, with multimodal new therapies.Aims: To assess cure rates of different therapeutic protocols and the impact of these therapies on survival.Methods: 334 patients (224 F/110 M, mean age 48.1±0.7 years) with acromegaly admitted in a single Neuroendocrinology Department between Jan 2001 and Dec 2013 were retrospectively studied by GH...

ea0035p734 | Neuroendocrinology | ECE2014

Efficacy of early postoperative radiotherapy for nonfunctioning null cell or silent pituitary macroadenomas

Stancu Cristina , Gheorghiu Monica Livia , Galoiu Simona , Anghel Rodica , Badiu Corin , Coculescu Mihail

Background: Suitable postoperative radiotherapy (RT) of nonfunctioning pituitary macroadenomas (NFMAs) is still controversial, subjected to rapid technical and medical progress.Patients and methods.: We studied 87 patients with NFMA to identify factors affecting tumor control such as the time of RT and tumor pathology. Partial pituitary surgery was performed either by transfrontal (30 patients) or transsphenoidal (57 patients) approach. An immunoperoxida...

ea0035p921 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Increased prevalence of differentiated thyroid carcinoma in patients with acromegaly

Serban Andreea , Trifanescu Raluca , Niculescu Dan , Carsote Mara , Galoiu Simona , Goldstein Andrei , Poiana Catalina

Background: Acromegaly is associated with increased prevalence of thyroid diseases, particularly of differentiated thyroid carcinoma.Aim: To assess prevalence of thyroid diseases and thyroid cancer in patients with acromegaly.Patients and methods: Forty (10 M/30 F) acromegalic patients, 14 residents in iodine deficient areas, aged 47±12.8 years, were retrospectively reviewed. Mean duration of acromegaly was 7.6±9.5 years ...