Endocrine Abstracts

Nowadays fat tissue is considered as endocrine organ responsible for metabolism of sex hormones. Obesity is accompanied by a decrease in biosynthesis of 17β-estradiol (2-hydroxyestrone) inactive metabolites and increased production of aggressive metabolites (16-hydroxyestrone). This factor leads to hyperproliferative syndrome, which includes hormonal-dependent lesions of target organs: uterine leiomyomas, adenomyosis, hyperplasia of endometrium, tumor-like lesions of the ...

Background: Aromatase inhibitors have been introduced as a new treatment modality in controlled ovarian stimulation as they were found to elevate follicular sensitivity to gonadotropins.The purpose of this study was to evaluate whether IVF outcomes will differ between poor responder patients who receive high doses of gonadotropins alone or low doses of gonadotropins with letrozole during ovulation stimulation.Methods: Patients who ...