Searchable abstracts of presentations at key conferences in endocrinology

ea0104p85 | Diabetes & Metabolism | SFEIES24

A novel bipyrazole compound as a potential therapeutic agent for diabetes mellitus through PGK1/AKT activation

Alqudah Abdelrahim , Qnais Esam , Abu-Safieh Kayed , Gammoh Omar , Wedyan Mohammed , Alqudah Mohammed

Background: Diabetes mellitus type 2 (T2D) is a prevalent metabolic disorder characterized by insulin resistance and high blood sugar levels. Existing treatments focus on managing these symptoms, but there is an ongoing need for more effective interventions. Our study explores the potential of 2′,3,3,5′-Tetramethyl-4′-nitro-2′H-1,3′-bipyrazole (TMNB) in this context, based on its presumed impact on oxidation, glycation, and insulin resistance proc...