Searchable abstracts of presentations at key conferences in endocrinology

ea0014p154 | (1) | ECE2007

TGFß1 signalling in human insulinomas compared with human islets.

Nabokikh Anastasiya , Bilban Martin , Gartner Wolfgang , Vila Greisa , Niederle Bruno , Nielsen Jens , Zielinski Christoph , Luger Anton , Wagner Ludwig

Insulinomas are thought to be the result of reduced ß-cell death and hyperproliferation of this specific and highly differentiated cell type. Specific growth- factors are responsible for inducing ß- cell replication and might therefore be involved in insulinoma formation. Pluripotent islet progenitor cells are thought to be located at pancreatic ducts, which can give rise to novel islets as well as exocrine pancreas formation. TGFß1 signalling disruption has bee...

ea0014p269 | (1) | ECE2007

Characterization of the rat homologue of the human neuroendocrine marker secretagogin – new functional implications by in vitro studies

Gartner Wolfgang , Vila Greisa , Daneva Teodora , Koc-Saral Felic , Majdic Otto , Nabokih Anastasia , Luger Anton , Wagner Ludwig

Objective: Establishment of rodent in vitro cell systems for the extension of the functional data about the recently cloned neuroendocrine marker secretagogin.Methods: 1. DNA-cloning; 2. Antibody generation; 3. Immunoblotting and Immunohistochemistry; 4. Cell-transfection; 5. Luciferase Reporter Assays; 6. ELISA.Results: 1. We characterized the rat homologue of human secretagogin (rat secretagogin) and demonstrated the homol...