Searchable abstracts of presentations at key conferences in endocrinology

ea0070s6.3 | Adrenocortical carcinoma | ECE2020

ACC - what’s new today; where is hope tomorrow

Hammer Gary

Adrenocortical Carcinoma (Adrenal Cancer or ACC) is a rare malignancy. It requires multidisciplinary care to manage the multiple endocrine and oncologic manifestations of the disease. We will use the recently published international ACC Guidelines to illustrate essential components of the standard of care work-up, diagnosis, and management of ACC. As an understanding of genetics is becoming increasingly mainstream in cancer biology and care including adrenocortical carcinoma (...

ea0019s18 | What's Wnt? A novel signalling pathway in endocrinology | SFEBES2009

Wnt signaling in adrenal stem/progenitor cells: implications for organ homeostasis and cancer

Hammer Gary

The long range objective of my laboratory is to understand the cellular and molecular mechanisms by which signaling pathways and downstream transcription factors coordinate the specification of adrenocortical cells within the adrenal gland in health and disease. Recent efforts examine the hypothesis that Wnt/╬▓catenin signaling maintains the functional capacity of the adrenal cortex though the regulation of undifferentiated adrenocortical cell fate. Dysregulation of this s...

ea0081yi12 | Young Investigator Awards | ECE2022

Role of the transcription factor HHEX in inner adrenal cortex homeostasis and response to progesterone signaling

Dumontet Typhanie , Basham Kaitlin , Lerario Antonio , Bothou Christina , Brixius Bjoern , Turcu Adina F , Beuschlein Felix , Hammer Gary D

The adrenal glands serve as central organs of the endocrine system by producing steroid hormone essential for organismal homeostasis. Mechanisms ensuring proper adrenal homeostasis and function are therefore crucial for maintaining human life. ACTH, released by the pituitary corticotrope, is required for the differentiation of the inner part of the adrenal cortex (the zona fasciculata) and the resultant stimulation of cortisol production. Perturbation of ACTH signaling can lea...

ea0081p389 | Endocrine-Related Cancer | ECE2022

Znrf3 inactivation leads to a sexually dimorphic immune microenvironment in adrenocortical tumorigenesis

Olabe Julie , James Wilmouth , Kaitlin Basham , Cecily Lucas , Florence Roucher-Boulez , Igor Tauveron , Anne-Marie Lefrancois-Martinez , Laura-Sophie Landwehr , Matthias Kroiss , Martin Fassnacht , Gary Hammer , Antoine Martinez , Pierre Val

Adrenocortical carcinoma (ACC) is a rare and aggressive cancer that originates from steroidogenic cells within the adrenal cortex. The most common alteration in ACC patients is inactivation of the transmembrane E3 ubiquitin-ligase Zinc and Ring Finger 3 (ZNRF3), which is responsible for inhibiting the canonical WNT/Beta-catenin pathway. Using Cre/loxP strategy, we showed that inactivation of Znrf3 in the adrenal cortex resulted in an initial hyperplasia by 6-weeks, af...