Searchable abstracts of presentations at key conferences in endocrinology

ea0015p322 | Steroids | SFEBES2008

Serine phosphorylation of IRS-1 as a mechanism of glucocorticoid induced insulin resistance in mouse C2C12 myotubes

Morgan Stuart A , Gathercole Laura L , Bujalska Iwona , Stewart Paul M , Smith David , Tomlinson Jeremy W

Glucocorticoid (GC) excess is characterized by increased adiposity, skeletal myopathy and insulin resistance. Despite the increasing use of GCs as therapeutic agents, the molecular mechanisms that underpin GC mediated changes in insulin signalling are not clear. Within skeletal muscle, the microsomal enzyme, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts inactive GC, 11-dehydrocorticosterone (A) to active corticosterone (B) and thus regulates GC availabi...

ea0067o30 | Oral Presentations | EYES2019

AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease

Nikolaou Nikolaos , Gathercole Laura L , Marchand Lea , Althari Sara , Dempster Niall J , Green Charlotte J , van de Bunt Martijn , McNeil Catriona , Arvaniti Anastasia , Hughes Beverly A , Sgromo Bruno , Gillies Richard S , Ryan John , Arlt Wiebke , Hodson Leanne , Tomlinson Jeremy W

Objective: Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome. Steroid hormones and bile acids are potent regulators of hepatic carbohydrate and lipid metabolism. Steroid 5β-reductase (AKR1D1) is highly expressed in human liver where it inactivates steroid hormones and catalyzes a fundamental step in bile acid synthesis.Methods: Human liver biopsies were obtained from 34 obese patients and AKR1D1 mRNA expres...