Searchable abstracts of presentations at key conferences in endocrinology

ea0094oc6.3 | Metabolism, Obesity and Diabetes | SFEBES2023

Sex hormone contribution to sex differences in a mouse model of beta cell endoplasmic reticulum (ER) stress

Gatward Lydia Daniels , Doherty Lucy , Khot Shreya , Gonzalez Dominguez Carolina , Ruent Sigrid , King Aileen

The KINGS mouse harbours a mutant Ins2 which drives beta cell ER stress, however only males develop diabetes. Since diabetes incidence is lower in women and ER stress is implicated in human diabetes, we investigated the influence of oestrogen and testosterone in mediating sex differences in the KINGS mouse. To investigate the influence oestrogen (E2) and testosterone removal on glycaemic control, male (n =4-6) and female (n =9) KINGS mice underwent p...