Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1 | Adrenal cortex | ICEECE2012

Targeting mutated β-catenin in vitro and in vivo inhibits cell proliferation and stimulates apoptosis: a promising therapeutic target in adrenocortical carcinoma

Ragazzon B. , Gaujoux S. , Hantel C. , Tissier F. , Rizk-Rabin M. , Beuschlein F. , Bertherat J.

Adrenocortical carcinoma (ACC) is a rare and highly aggressive endocrine neoplasm, with limited therapeutic option. Activating β-catenin somatic mutations are observed in ACC and associated with a poor outcome. Activation of the Wnt/β-catenin signaling pathway seems to play a major role in ACC aggressiveness, and might be a promising therapeutic target. The H295 cell line derived from an ACC harbors an activating β-catenin mutation. We herein assess the in vi...