Endocrine Abstracts

Obesity and diabetes mellitus type 2 are proinflammatory states associated with increased disease severity in rheumatoid arthritis (RA). Weight loss is associated with improved disease activity in rheumatoid arthritis (RA). Furthermore science experiments demonstrated weight-independent anti-inflammatory and immunomodulatory effects of GLP-1 receptor agonists. Moreover, in vitro studies found anti-inflammatory effects of GLP-1 receptor agonists in fibroblast-like syno...

Interferon gamma-induced protein 10, a proinflammatory chemokine, has a significant effect in inflammatory diseases. Interferon-inducible protein of 10 kD (IP-10/CXCL10), is a member of the C-X-C chemokine superfamily. It is a potent chemoattractant for activated T lymphocytes and is reported to be involved in various disease states, including atheroma plaque formation, inhibition of tumor angiogenesis and maintenance of podocyte function. However, the involvement of IP-10 in ...