ea0099p465 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024
da Silva Hellen
, Amelia Montenegro Maria
, Gebenlian Juliana
, Antunes Rodrigues Jose
, de Paula Francisco
, Elias Lucila
Non-alcoholic fatty liver disease (NAFLD) is characterized by the pathological increase of lipid droplets, altered fat metabolism in hepatocytes and increased inflammation. Phosphodiesterase 4 (PDE4) modulates the inflammatory responses and its inhibitor can strongly reduce TNF-α release and inflammation. Additionally, PDE4 knockout mice were shown to be resistant to diet-induced obesity (DIO). The aim of this study was to investigate the role of pharmacological PDE4 inhi...