Endocrine Abstracts

The cytoskeletal acting-binding protein filamin A (FLNA) is poorly expressed in adrenocortical carcinomas (ACC) compared to adenomas (ACA), and this might contribute to sustain the increased cell proliferation by upregulating IGF1R and its downstream signaling. An increased expression of the CDK1 kinase Wee1, a leading gatekeeper for G2/M transition, was shown in mouse neural progenitor cells after loss of FLNA. Wee1 is highly expressed in several tumor types and its pharmacol...