ea0011oc1 | Signal transduction OC1 Novartis Oncology Young Investigator Award | ECE2006
Patchev AV
, Fischer D
, Herkenham M
, Götz F
, Wolf SS
, Gehin M
, Chambon P
, Patchev VK
, Almeida OFX
Efficiency of glucocorticoid receptor (GR) signaling is modulated by a variety of co-activators, including the transcription intermediary factor 2 (TIF-2). Although TIF-2 has been shown to amplify GR signaling in different cellular models and contexts, its system-physiological relevance has not been comprehensively examined. The present work investigated the role of TIF-2 in GR-mediated regulation of hypothalamo-pituitary-adrenal (HPA) axis activity in mice. Experiments were d...