ea0084ps2-09-80 | Thyroid Hormone ACTION | ETA2022
Lopez Alcantara Nuria
, Geissler Cathleen
, Naujack Alison-Michelle
, Chen Yingfu
, Taege Natalie
, H. Britsemmer Jan
, Vinicius Monteiro De Assis Leonardo
, Oster Henrik
, Spranger Joachim
, Katrin Wirth Eva
, Nogueiras Ruben
, Kirchner Henriette
, Mittag Jens
Background and Aim: Altered hepatic thyroid hormone (TH) signalling is associated with the onset and progression of liver diseases. Local hepatic hypothyroidism is related to a higher incidence of developing non-alcoholic fatty liver disease (NASH) in humans and animal models. Thyroid hormone treatment proved to be a promising therapy, slowing the progression of NAFLD to non-alcoholic steatohepatitis (NASH), a more advanced stage of the disease characterized by inflammation an...