Searchable abstracts of presentations at key conferences in endocrinology

ea0016p529 | Obesity | ECE2008

Determination of dimerisation domains of the human melanocortin 4 receptor

Genetzky Jessica , Tarnow Patrick , Rediger Anne , Gruters Annette , Biebermann Heike

The melanocortin 4 receptor (MC4R), a G protein coupled receptor, has a prominent role in hypothalamic weight regulation. The MC4R was recently shown to form receptor dimers. The cannabinoid 1 receptor (CB1R) is the nearest phylogenetic relative of MC4R but fails to interact with the MC4R in vitro. In this study we aim to investigate receptor domains that are necessary for MC4R interaction. Four different chimeric receptors of MC4R and CB1R were constructed. The generated cons...