Searchable abstracts of presentations at key conferences in endocrinology

ea0035oc10.2 | Endocrine Tumours | ECE2014

The cytotoxic effect of sunitinib on human bronchial carcinoid cell lines and primary cultures is counteracted by EGF and IGF-1 but not by VEGF

Gagliano Teresa , Gennari Giulia , Tassinari Martina , Bellio Mariaenrica , Gentilin Erica , Benfini Katiuscia , Uberti Ettoredegli , Zatelli Maria Chiara

Background: Bronchial carcinoids (BC) are rare tumors originating from endocrine cells dispersed in the respiratory epithelium. The main BC treatment is surgery, which is not feasible for large, infiltrating and metastatic disease. In these settings, medical therapy is often tried. Therefore it is important to identify new therapeutic targets and new molecules capable of providing adequate medical treatment for patients with BC. Sunitinib, is an oral, small-molecule, multi-tar...