Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep786 | Endocrine tumours and neoplasia | ECE2017

Potential role of vitamin D in restoring sensitivity to mTOR inhibitors in hepatocellular carcinoma (HCC): 1,25(OH)vitamin D (VitD) reverts everolimus (EVE) resistance in a hcc cell line

Pivonello Claudia , Provvisiero Donatella Paola , Negri Mariarosaria , Gennaro Gilda Di , de Angelis Cristina , Simeoli Chiara , Galdiero Giacomo , Martino Maria Cristina De , Colao Annamaria , Pivonello Rosario

HCC is a difficult-to-treat- cancer with poor prognosis. Despite EVOLVE-1 trial demonstrated that EVE did not improve overall survival in molecularly and clinically unselected patients with advanced sorafenib resistant HCC, in selected patients, the established antitumor effect of EVE could make this drug a potential adjuvant therapy. Unfortunately, the acquired EVE resistance due to the tumour adaptation to chronic drug use is a current challenge. VitD has been deemed as pote...

ea0056p387 | Diabetes (to include epidemiology, pathophysiology) | ECE2018

The effect of the dopamine agonist cabergoline on insulin sensitivity in the skeletal muscle: an in vitro study in a mouse cell model demonstrating mediation by serotoninergic receptors

Negri Mariarosaria , Pivonello Claudia , Gennaro Gilda Di , Angelis Cristina de , Simeoli Chiara , Iacuaniello Davide , Nettore Immacolata Cristina , Macchia Paolo Emidio , Muscogiuri Giovanna , Colao Annamaria , Pivonello Rosario

Insulin resistance (IR), characterized by an impairment of target tissues to insulin responsiveness, is the core defect preceding diabetes. Preclinical and clinical data have suggested a role for the dopaminergic system in glucose homeostasis control. The aim of the current study was to investigate the role of the dopamine agonist cabergoline (CAB), displaying high affinity for dopamine type 2 (DR2) receptor and low affinity for serotonin receptors (5-HTRs), in the regulation ...