ea0029p1432 | Pituitary Clinical | ICEECE2012
Persechini M.
, Gennero I.
, Grunenwald S.
, Vezzosi D.
, Bennet A.
, Caron P.
Introduction: In women with GH-secreting pituitary adenoma, a decrease of IGF1 levels has been reported during the first trimester of pregnancy, before placental GH (pGH) secretion inducing a progressive increase in IGF1 levels throughout gestation. This decrease has been related to hepatic GH-resistant state, via JAK2/STAT pathway, due to increased estrogen (E2) levels.Objectives: Evaluate IGF1 change in non-acromegalic women during the first...