Searchable abstracts of presentations at key conferences in endocrinology

ea0026p524 | Bone/calcium/Vitamin D | ECE2011

Association of the A1330V and V667M polymorphisms of LRP5 with bone mineral density in Greek peri- and postmenopausal women

Markatseli A , Hatzi E , Bouba I , Georgiou I , Challa A , Tigas S , Tsatsoulis A

Wnt signaling through low-density lipoprotein receptor-related protein 5 (LRP5) is an important determinant of bone mass regulation. Polymorphisms in the LRP5 gene have been associated with either osteoporotic phenotypes or normal bone mineral density (BMD) variation.Objective: To explore the influence of two LRP5 single nucleotide polymorphisms (SNPs) A1330V and V667M on BMD and serum levels of osteoprotegerin (OPG), receptor activator of nuclear factor...

ea0026p102 | Female reproduction | ECE2011

The importance of PIK3R1 gene in polycystic ovary syndrome

Xita N , Chatzikyriakidou A , Georgiou I , Tsatsoulis A

Introduction: Insulin resistance is a main characteristic of polycystic ovary syndrome (PCOS) and contributes to the increased risk of type 2 diabetes and cardiovascular disease. It is thought that in PCOS there is an alteration in the insulin signaling pathway. An important kinase in this pathway is the phosphatidylinositol 3 kinase (PI3K), the activity of which has been found to be decreased in PCOS. Based on this observation we investigated whether a single nucleotide polym...

ea0026p103 | Female reproduction | ECE2011

Effect of paraoxonase genes on metabolic profile of women with polycystic ovary syndrome

Xita N , Lazaros L , Georgiou I , Tsatsoulis A

Introduction: Increased oxidative stress is considered to be implicated in the pathophysiology of polycystic ovary syndrome (PCOS). While the regulation of oxidative stress is multifactorial, many studies have been focused on the antioxidant role of paraoxonase (PON). The aim of this study was to investigate the possible association of the Q192R and the L55M polymorphisms of PON1 and the Ser311Cys polymorphism of PON2 with PCOS.Subjects and...

ea0011p675 | Reproduction | ECE2006

Evidence for synergy of SHBG and androgen receptor genes in PCOS phenotype

Xita N , Georgiou I , Psofaki V , Kolios G , Tsatsoulis A

Polycystic ovary syndrome (PCOS) is a common endocrinopathy with hyperandrogenemia to be its strongest genetically determined characteristic. Our aim was to investigate the potential synergy of two functional polymorphisms: the (TAAAA)n polymorphism of the sex hormone-binding globulin gene (SHBG) known to be associated with PCOS and influence serum SHBG levels (longer repeats were associated with lower SHBG levels) and the (CAG)n polymorphism of androgen receptor gene (...

ea0029p907 | Female Reproduction | ICEECE2012

Association of the (TAAAA)n repeat polymorphism of SHBG gene with age at menopause in Greek postmenopausal women

Markatseli A. , Hatzi E. , Bouba I. , Xita N. , Tigas S. , Georgiou I. , Tsatsoulis A.

Introduction: Sex hormone-binding globulin (SHBG) regulates the bioavailability of sex steroid hormones, which in turn regulate reproductive function. The potential association of SHBG gene polymorphisms with the age at menopause has not been examined.Objective: The present study aimed to assess the possible relationship between the pentanucleotide (TAAAA)n repeat polymorphism in the promoter of the SHBG gene and the age at menopause in a Greek fe...

ea0011p332 | Diabetes, metabolism and cardiovascular | ECE2006

The severity of cardiovascular disease in women is modified by estrogen receptor alpha polymorphic variants

Alevizaki M , Saltiki K , Kanakakis I , Cimponeriu A , Alevizaki C , Georgiou I , Anastasiou E

Impaired estrogen (E2) action is important for cardiovascular disease (CAD) in both men and women. Associations of CAD with estrogen receptor polymorphisms, which may influence sensitivity to E2 have been reported for men but have not been confirmed for women. The aim of the present study was to investigate the association of estrogen receptor common polymorphisms with the severity of coronary disease in women undergoing coronary angiography.Estrogen rec...