Searchable abstracts of presentations at key conferences in endocrinology

ea0020p678 | Signal Transduction | ECE2009

The MAPKinases ERK1/2 take centre stage in somatotroph physiopathology

Pertuit Morgane , Romano David , Barlier Anne , Enjalbert Alain , Gerard Corinne

Somatotroph pituitary adenomas are characterized by unrestrained hormone secretion and cell proliferation alterations. In those tumors, the only mutation so far unequivocally identified is the gsp oncogene (Gsα protein gain of function mutation). Nethertheless, there is no clear difference in the clinical phenotypes of patients bearing tumor with the gsp oncogene (gsp+) or not (gsp−). In addition, an overexpression of the wild-type Gsα protein has been o...

ea0032s11.3 | New mechanisms in SST analogue response | ECE2013

Role of ERK in somatostatin receptor signalling

Barlier Anne , Romano David , Zeiller Caroline , Roche Cathy , Pertuit Morgane , Gerard Corinne

The Ras/Raf/MEK/ERK is a conserved signalling pathway involved in the control of fundamental cellular processes. Despite extensive research, how this pathway can process a myriad of diverse extracellular inputs into specific biological outcomes is not fully understood. Particularly, the role of this pathway in neuroendocrine tumoral cells remains unclear.We have previously shown that the ERK1/2 pathway is an integrative point in the control of the pituit...

ea0032p334 | Developmental Endocrinology | ECE2013

Somatostatin receptor sst2 transfer in somatolactotroph cell line. Constitutive activity and drug sensitivity

Roche Catherine , Graillon Thomas , Rasolonjanahary Ramahefarizo , Thirion Sylvie , Enjalbert Alain , Gerard Corinne , Barlier Anne

Somatostatin is a ubiquitous neuropeptidic inhibitor of various cellular functions including endocrine and exocrine secretion. Moreover, this peptide may control cell proliferation in normal and tumoral tissues. Somatostatin biological effects are mediated by five subtype of G protein-coupled receptor, sst1 through sst5. The somatostatin analogs have high affinity for sst2 receptor and the success of in vivo peptide therapy is correlated with high levels of sst2 in th...

ea0022p724 | Signal transduction | ECE2010

Spatial and temporal regulations of MAPKinases ERK1/2 in the somatolactotroph cell line GH4C1

Zeiller Caroline , Blanchard Marie-Pierre , Pertuit Morgane , Thirion Sylvie , Enjalbert Alain , Barlier Anne , Gerard Corinne

Somatotroph adenomas are characterized by growth hormone hypersecretion and cell proliferation. We have previously identified crosstalk between the cAMP pathway and the MAPKinases ERK1/2 cascade and shown the central place of the MAPKinases in the control of the pituitary function in GH4C1 somatolactotroph cell line.The spatio-temporal organization of the signalling partners governs signalling fidelity and encodes the specificity of biological responses....