Searchable abstracts of presentations at key conferences in endocrinology

ea0026s16.3 | TSH Receptor and thyroid disorders | ECE2011

Small molecule TSH receptor agonists and antagonists

Neumann S , Gershengorn M C

TSH activates the TSH receptor (TSHR) thereby stimulating the function of thyroid follicular cells (thyrocytes) leading to biosynthesis and secretion of thyroid hormones. Because TSHR is involved in several thyroid pathologies there is a strong rationale for the design of small molecule ‘drug-like’ ligands (SMLs).rhTSH (ThyrogenR) has been used in the follow-up of patients with thyroid cancer to increase the sensitivity for detection...