Endocrine Abstracts

TSH activates the TSH receptor (TSHR) thereby stimulating the function of thyroid follicular cells (thyrocytes) leading to biosynthesis and secretion of thyroid hormones. Because TSHR is involved in several thyroid pathologies there is a strong rationale for the design of small molecule ‘drug-like’ ligands (SMLs).rhTSH (ThyrogenR) has been used in the follow-up of patients with thyroid cancer to increase the sensitivity for detection...