Searchable abstracts of presentations at key conferences in endocrinology

ea0037oc10.1 | Nuclear receptors and signalling | ECE2015

Resistin negatively regulates neuronal adiponectin signalling through the down regulation of APPL1 and adiponectin receptors

Benomar Yacir , Gertler Arieh , Taouis Mohammed

Obesity is linked to common metabolic diseases including insulin resistance, which constitutes a principal risk factor for type 2 diabetes. Increasing evidence indicates that changes in adipose-secreted factors in obesity, dramatically affect insulin sensitivity. Among these adipokines, resistin is described as a key factor in obesity-mediated both inflammation and insulin resistance. However, little is known about the molecular mechanisms mediating resistin effects particular...

ea0037oc11.1 | Obesity | ECE2015

Central resitin infusion impairs FGF21/FGFR1/β-Klotho hypothalamic expression and promotes peripheral FGF21 resistance: involvement of resistin/TLR4 signalling pathway

Benomar Yacir , Amine Hamza , Gertler Arieh , Taouis Mohammed

FGF21 has recently emerged as a major regulator of metabolism and energy utilisation. FGF21 administration confers multiple metabolic benefits on insulin sensitivity, blood glucose, lipid profile and body weight in rodents and primates. FGF21 acts through a receptor complex consisting of FGF receptors (FGFR 1, 2, 3 or 4) and a co-receptor βKlotho (KLB), crucially required for FGF21 signaling. Although FGFRs are widely expressed, KLB is predominantly expressed in adipose t...

ea0037ep167 | Reproduction, endocrine disruptors and signalling | ECE2015

Palmitic acid enhances TLR4 expression and promotes resistin/TLR4 signalling

Amine Hamza , Benomar Yacir , Gertler Arieh , Taouis Mohammed

Toll-like receptor 4 (TLR4) has a critical role in innate immunity, and the activation of inflammatory pathways plays an important role in the induction of insulin resistance. Indeed, we have recently demonstrated that TLR4 is implicated in resistin-induced inflammation and insulin resistance in the hypothalamus.1 We have also shown that TLR4 is up-regulated in the hypothalamus of mice fed a high-fat diet. Here, we aim to decipher the molecular mechanisms implicated...

ea0037gp.15.04 | Diabetes and obesity – basic | ECE2015

Novel human resistin antagonist (monomeric C6A mutant) reduced body weight gain and restored insulin responsiveness in mice fed high fat diet

Benomar Yacir , Solomon Gili , Amine Hamza , Othmane Ahlem , Gertler Arieh , Taouis Mohammed

Resistin promotes both inflammation and insulin resistance associated with energy homeostasis impairment. Resistin is secreted by adipose tissue and macrophages, but its mechanism of action remained unknown because its receptor was not characterised. Recently, we have shown that central resistin acts by way of hypothalamic TLR4 receptors promoting overall inflammation and insulin resistance. Here, we aim to block resistin action in HFD mice that are prone to obesity and inflam...

ea0014p11 | (1) | ECE2007

Blocking undesired leptin action in vivo with leptin antagonists prepared by site-directed mutagenesis of human, ovine, rat and mouse leptin site III

Niv-Spector Leonora , Gonen - Berger Dana , Salomon Gili , Callebaut Isabelle , Djiane Jean , Gertler Arieh

Recent reports have revealed that leptin’s effects are not restricted to central control of body weight, demonstrating instead that leptin is a pleiotropic hormone with a wide variety of different biological actions. Leptin exhibits undesirable effects in autoimmune diseases, in atherosclerosis, and possibly in several types of cancer, and increases the risk of cardiovascular disease in obese people. Therefore, preparation of reagents capable of abolishing leptin’s a...