Endocrine Abstracts

Introduction: Somatotropinomas are benign pituitary tumors with heterogeneous biological and clinical behavior. The tumor microenvironment (TME) is an environment generated by the interaction between tumor cells and the host immune system. It affects both the behavior of the tumor and the outcome of the therapy. The GNAS gene encodes the alpha subunit of G proteins associated with hormone receptors such as TSH, PTH, GHRH, FSH/lH, ACTH. Mutation of this gene has been associated...

Somatotropinomas are benign pituitary tumors, with a heterogenous biological and clinical behavior. Tumor microenvironment reflects the interaction between tumor cells and the host immune system and may regulate tumor behavior and therapy outcome. We develop a scoring system that includes clinical, pathological and immune markers to early identify fg-SRLs resistant acromegaly pts. 43 acromegaly pts were included according the following criteria (1) first line treatment with su...

Introduction: The Morris syndrome, is a rare X-linked disorder in which patients with XY chromosomal makeup (corresponding to a male genotype) develop female sexual characteristics. Acromegaly is a rare disease related to excessive production of growth hormone (GH) and insulin growth factor-I (IGF-I). Rarely, acromegaly was reported to be associated to a chromosomal microduplications of Xq26.3, responsible for early onset form of acro-gigantism. However, cases of acromegaly as...

Background: Pegvisomant(PegV) and Pasireotide LAR(Pasi) are commonly used in acromegaly patients resistant to first-generation SRLs. Predictors of response to therapy with PegV and Pasi in this subset of patients are still unclear. These findings may be useful in choosing the most appropriate therapeutic option for the personalized treatment of patients affected by more aggressive disease. We aimed to identify individual predictors of responses.Methods: ...

Introduction: Infundibulo-neurohypophysitis (INH) is an uncommon inflammatory disorder. Because of the location of inflammation, it selectively affects the neuropituitary and pituitary stalk. The differential diagnosis remains often challenging with neoplastic lesions, such as germ cell neoplasia, Langerhans cell histiocytosis, Erdheim-Chester Disease, metastasis. Our clinical case is emblematic for pitfalls in diagnosis of the pituitary stalk lesionCase...

Background: Pituitary metastases are rare findings and account for 1% of surgically treated pituitary lesions. Despite the low incidence, given the frequent compression exerted on surrounding structures, pituitary metastases can present with major symptoms such as headache, visual disturbances and visual field. Ultimately, damage to the pituitary gland may be associated with electrolyte disturbances.Clinical case: A 57-year-old male patient was admitted ...