Searchable abstracts of presentations at key conferences in endocrinology

ea0056p47 | Adrenal cortex (to include Cushing's) | ECE2018

The renin-angiotensin-aldosteron system in primary adrenal insufficiency

Wolf Peter , Mayr Johanna , Poglitsch Marko , Gessl Alois , Luger Anton , Winhofer Yvonne , Krebs Michael

Background: Despite adequate hormone replacement therapy, evidence suggests that mortality is increased in patients suffering from primary adrenal insufficiency (AI), mainly because of cardiovascular diseases. Since activation of the renin-angiotensin-aldosteron system (RAAS) plays an important role in the development of hypertension and cardiovascular disease we aimed to investigate, if there are differences in AI compared to healthy controls.Methods: E...

ea0056gp203 | Pituitary Clinical | ECE2018

Factors predicting comorbidities in cured patients with Cushing’s syndrome

Schernthaner-Reiter Marie Helene , Siess Christina , Gessl Alois , Scheuba Christian , Wolfsberger Stefan , Riss Philipp , Knosp Engelbert , Luger Anton , Vila Greisa

Introduction: In patients with cured Cushing’s syndrome, comorbidities often persist after remission of glucocorticoid excess. Here we investigate long-term comorbidities in patients with Cushing’s syndrome in remission, and their relationship to metabolic and hormonal markers at the initial diagnosis of the disease.Methods/design: We evaluated 118 patients with cured Cushing’s syndrome (55 Cushing’s disease, 55 adrenal Cushing’s...

ea0063gp189 | Adrenal and Neuroendocrine - Clinical | ECE2019

Plasma renin concentration is associated with cardiac function and morphology in primary adrenal insufficiency

Wolf Peter , Beiglbock Hannes , Fellinger Paul , Pfleger Lorenz , Aschauer Stefan , Gessl Alois , Trattnig Siegfried , Kautzky-Willer Alexandra , Luger Anton , Winhofer Yvonne , Krssak Martin , Krebs Michael

Background: Despite adequate glucocorticoid (GC) and mineralocorticoid (MC) replacement therapy, primary adrenal insufficiency (AI) is associated with an increased mortality, mainly due to cardiovascular disease. The role of MC replacement is not known. Therefore we assessed whether renin concentrations during routine GC and MC substitution therapy are associated with cardiac function and morphology.Methods: 17 patients with AI underwent magnetic resonan...

ea0037ep720 | Pituitary: clinical | ECE2015

No evidence of impaired oral hormone substitution after gastric bypass surgery in patients with morbid hypothalamic obesity and hypopituitarism secondary to craniopharyngioma

Wolf Peter , Winhofer Yvonne , Smajis Sabina , Kruschitz Renate , Schindler Karin , Gessl Alois , Vila Greisa , Raber Wolfgang , Langer Felix , Prager Gerhard , Ludvik Bernhard , Luger Anton , Krebs Michael

Background: Craniopharyngiomas (CP) are benign brain tumours presenting in childhood treated by tumour resection together with radiotherapy. In about half of the cured patients hypothalamic damage leading to eating disorders and obesity as well as to hypopituitarism, necessitating consequent hormone substitution therapy, is observed. Bariatric surgery is an efficient treatment strategy for morbid obesity. However, so far it is unknown, whether oral hormone substitution is hamp...

ea0032p982 | Thyroid (non-cancer) | ECE2013

PRIMARA: a prospective descriptive observational study to review cinacalcet use in patients with primary hyperparathyroidism in clinical practice

Schwartz Peter , Body Jean-Jacques , Cap Jan , Hofbauer Lorenz , Farouk Mourad , Gessl Alois , Kuhn Marc , Marcocci Claudio , Mattin Caroline , Munoz Torres Manuel , Payer Juraj , van de Ven Annenienke , Yavropoulou Maria , Selby Peter

PRIMARA is the first observational study to describe the demographic and clinical profiles of adults with primary hyperparathyroidism (pHPT) receiving cinacalcet in daily clinics across European countries.Patients with pHPT aged ≥18 years without prior cinacalcet treatment were eligible. Initial cinacalcet dosage and subsequent dose changes were at the investigator’s discretion. Information on dosing, biochemistry and adverse drug reactions (A...