Endocrine Abstracts

Thyroid stimulating hormone (TSH) causes synthesis of 90% of pro-hormone tetraiodothyronine (T4) and 10% of active triiodothyronine (T3) from thyroid gland. T3 regulates energy metabolism, thermogenesis, body temperature and normal brain development. T3 is produced from deiodination of T4 and circulating levels of T3 are regulated by deiodinases in response to body’s needs. The peripheral conversion of T<su...

Ghrelin receptor GHSR1α is expressed in hypothalamo–pituitary–gonadal tissues. Ghrelin reduces GnRH secretion in pre-pubertal period and concentrations of ghrelin are positively correlated with testosterone at adulthood. Nevertheless, the role of ghrelin in affecting pituitary and gonadal functions during normal pubertal development remains elusive. A possible correlation between ghrelin and LH, FSH, testosterone and inhibin B was examined in boys (n=55...

The G protein coupled receptor of obestatin GPR39 is expressed in pituitary and gonads, indicating its possible role in regulation of pituitary and testicular function. The present study examined a possible association of obestatin with LH, FSH, testosterone, and inhibin B at puberty. Blood samples were collected from 10 to 20 years old boys (n=557) and concentrations of obestatin, LH, FSH, testosterone, and inhibib B were determined using specific ELISA. Data were an...

The reawakening of hypothalamo-pituitary-gonadal axis at puberty is influenced by a number of hormonal and genetic factors along with certain environmental cues. In boys, puberty is initiated at around 9 years of age as plasma concentrations of luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone (T) begin to rise leading to development of secondary sex characteristics. The absence of signs of sexual maturation at the age of 14/15 years is regarded as ...

Ghrelin, a putative signal of insufficient energy stores, increases in fasting states, decreases postprandially, and acts as a potent appetite stimulant increasing food intake. Obestatin affects appetite, food preferences to increase daily caloric intake and weight gain. Leptin regulates body fat mass, food intake and energy expenditure. Triiodothyronine (T3) is a determinant of adiposity, thermogenesis, glucose and lipid metabolism, appetite, food intake, and the o...