Searchable abstracts of presentations at key conferences in endocrinology

ea0056ep177 | Thyroid | ECE2018

Simultaneous medullary and papillary thyroid cancer in Graves-Basedow disease. Two case reports

Dumitriu Roxana , Petrova Eugenia , Buruiana Andra , Ghemigian Mircea , Ghemigian Adina

Introduction: The occurence of simultaneous medullary and papillary thyroid cancer is very rare. There were only 17 case reports in the literature, and fewer with Graves-Basedow disease associated. A retrospective study conducted at the National Institute of Endocrinology ‘C. I. Parhon’ showed that 7,6%of the patients who underwent total thyroidectomy for Graves-Basedow disease had thyroid cancer. Recent studies show that specific cellular pathways are determined by ...

ea0081ep181 | Calcium and Bone | ECE2022

Small and foudroyant parathyroid carcinoma with lung metastasis and no local invasion at diagnosis

Grigorie Daniel , Ghemigian Mircea , Ioachim Dumitru , Florescu Cristina , Sucaliuc Alina

Parathyroid carcinoma (PC) rarely presents with metastasis at diagnosis and usually in patients also having gross local invasion.Case presentation: We report the case of a 51-year-old postmenopausal woman presenting at our institution in June 2019 with symptomatic hypercalcemia (fatigue, polyuria, constipation and bone pain), but with a surprisingly good general condition. She had been treated with bisphosphonates for osteoporosis (DXA: LS T score &#8722...

ea0090ep590 | Endocrine-related Cancer | ECE2023

Incidental diagnosis of MEN2a in a patient with concurrent ovarian carcinoma presenting with cervical lymphadenopathies

Pena Catalina , Sucaliuc Alina , Mircea Ghemigian , Iulian Brezean , Nicoleta Dumitru Alida , Daniel Grigorie

Introduction: Multiple endocrine neoplasia type 2A is an autosomal dominant disorder which is characterized by the occurrence of medullary thyroid carcinoma in association with pheochromocytoma and parathyroid tumors.Case report: We present the case of a 64-year-old woman, with familial history of thyroid carcinoma, renal lithiasis and personal history of right nephrectomy for renal lithiasis, who presented for the investigation of a left lateral cervica...

ea0090ep652 | Endocrine-related Cancer | ECE2023

Different phenotype of familial RET mutation in 2 patients: Medullary thyroid carcinoma and Adrenal Paraganglioma

Naglabeala Laura , Milicescu Alexandra , Galoiu Simona , Braha Elena , Muresan Andrei , Ioachim Dumitru , Ghemigian Mircea , Poiana Catalina

Introduction: RET proto-oncogene is situated on chromosome 10 and encodes a tyrosine kinase receptor. A germline mutation of RET leads to the appearance of MEN 2 syndrome or familial medullary thyroid carcinoma (MTC). One of the most common germline mutation occurs in codon 634. Pheochromocytoma penetrance for codon 634 mutation was demonstrated to increase with age up to 88% by age 77 years.Aim: To present two familial cases of RET mutation illustrating...

ea0067gp2 | Poster Presentations | EYES2019

Coexistence of papillary thyroid cancer and sarcoidosis – how many associated complications?

Lazar Diana G , Oros Sabina E , Dobrescu Mariana , Dumitrescu Anda , Dumitru Ioachim , Goldstein Liviu , Ghemigian Mircea

Background: Papillary thyroid cancer (PTC) incidence has increased substantially over the last decades. Although 4% of thyroid cancers may induce a sarcoid reaction in the thyroid gland, sarcoidosis (SA) as a disease may exist with PTC, although causality remais uncertain and their coexistence is rarely reported in the literature. They occurs in both genres, between 30–40 years, but females are more predisposed.Case presentation: A 65-year-old man, ...

ea0022p178 | Clinical case reports and clinical practice | ECE2010

Glass fiber containing materials – a rare cause of granulomatous mastitis

Ghemigian Adina , Popescu Irina , Petrova Evghenia , Ioachim Dumitru , Ghemigian Mircea , Dumitrache Constantin

Foreign bodies represent a rare cause of granulomatous mastitis. In the last three years we diagnosed three women with granulomatous mastitis consecutive to exposure at building materials containing glass fibers. All of them were young (21–34 years), with regular menses, without any pathological histories and were admitted to our hospital for bilateral galactorrhea spontaneous in one case and by squeezing the nipple in the other two cases. Clinical and ultrasonographic ev...

ea0049ep1221 | Clinical case reports - Thyroid/Others | ECE2017

Clinicopathological characteristics and outcomes of differentiated thyroid carcinoma in children and adolescents

Goldstein Andrei Liviu , Chiriac Iulia Andreea , Ghemigian Adina Mariana , Procopiuc Camelia , Ghemigian Mircea Vasile , Brasoveanu Daniel , Goldstein Daniela , Purice Mariana , Alexiu Florin , Voicu Gabriela , Ioachim Dumitru , Gherlan Iuliana

Introduction: Differentiated thyroid carcinoma is a rare entity in pediatric population, with particularities in diagnosis, management and outcomes.Methods, aim: Retrospective noninterventional study describing clinical presentation and outcomes of children with DTC.Results: Between 2011 and 2017 54 children and adolescents aged 7.8–18 years (mean age at diagnoses 14.4 years) with DTC were diagnosed/followed up in our Institut...

ea0035p1099 | Thyroid Cancer | ECE2014

DNMT1 expression in papillary thyroid carcinoma

Brehar Andreea , Procopiuc Camelia , Paun Diana , Manda Dana , Oros Sabina , Caragheorgheopol Andra , Bulgar Alexandra , Brehar Felix , Dumitrescu Cristina , Gherlan Iuliana , Ghemigian Mircea , Stanescu Bogdan , Brasoveanu Daniel , Terzea Dana , Ioachim Dumitru , Plesa Adriana , Huica Irina , Iancu Iulia , Badiu Corin , Dumitrache Constantin

Introduction: In human cancer cells DNMTs are responsible for both de novo and maintenance methylation of tumor suppressor genes. Many studies have analyzed the relationship between the altered expression of DNMT1 and DNA methylation in cancer.Aim: To analyze DNMT1 expression in thyroid papillary carcinoma.Design: 49 patients aged 10–82 years hospitalized for thyroidectomy were included between January 2013 and July 2...

ea0035p1100 | Thyroid Cancer | ECE2014

Methylation status of HOXB4 gene in papillary thyroid carcinoma

Brehar Andreea , Procopiuc Camelia , Paun Diana , Manda Dana , Oros Sabina , Caragheorgheopol Andra , Bulgar Alexandra , Brehar Felix , Plesa Adriana , Iancu Iulia , Botezatu Anca , Ghemigian Mircea , Stanescu Bogdan , Brasoveanu Daniel , Terzea Dana , Ioachim Dumitru , Dumitrescu Cristina , Gherlan Iuliana , Badiu Corin , Dumitrache Constantin

Introduction: HOXB4 functions as a transcription factor involved in cell differentiation during embryogenesis and plays a role in apoptosis.Aim: This study analyzed HOXB4 methylation status in thyroid papillary carcinoma.Method: 54 patients aged 10–82 years hospitalized for thyroidectomy were included between January 2013 and July 2013. The inclusion criterion was patients with thyroid nodules with indication for surgery and t...