Searchable abstracts of presentations at key conferences in endocrinology

ea0003p291 | Thyroid | BES2002

Lithium associated thyrotoxicosis

Ghosh S , Bangar V

Hypothyroidism is common with lithium therapy. Thyrotoxicosis is rare. Of 81 cases of thyrotoxicosis related to lithium therapy reported 22 were silent thyroiditis , 39 Graves' disease and 11 autonomous nodule.We report a 56 year old male who had been on lithium for the last four years for bipolar illness, was referred to us when he was found to be biochemically thyrotoxic on routine testing. The TSH was less than 0.01, FT37.3, FT4 154. On his visit to ...

ea0002p9 | Clinical case reports | SFE2001


Ghosh S , Scobie I

A 41 year old male presented with erectile dysfunction associated with clinical hypogonadism (testosterone 0.8 nanomoles/litre). Hypopituitarism was confirmed on endocrine testing: Free T3 2.7 picomoles/litre, TSH 1.7 milliunits/litres, LH 0.6 units/litre, FSH 2.3 units/litre, PRL 34 units/litre, GH <0.5 milliunits/litre, IGF-1 10.5 nanomoles/litre, flat response of LH and FSH to Gn-RH, GH <0.5 milliunits/litre throughout ITT. (Cortisol rose from 197 to 523 nanomoles/lit...

ea0011p105 | Clinical case reports | ECE2006

Conn’s syndrome associated with hyperprolactinaemia: two case reports. Hypertension was cured by surgery in both cases despite a 10 and 16 year history

Talapatra I , Ghosh S , Tymms DJ

We describe two cases of Conn’s syndrome both of whom had hyperprolactinaemia of which one was associated with pituitary adenoma, possibly as part of MEN 1.The first patient was a man aged 52 who presented with hypertension present for 10 years and a marginally low serum potassium. He was on doxazosin, lisinopril, candesartan and celiprolol. His Aldosterone/Renin ratio (8500:1) was very high suggestive of primary hyperaldosteronism. The patient was ...

ea0005p192 | Neuroendocrinology and Behaviour | BES2003

Audit of quality of life in individuals who have undergone treatment for pituitary tumours over the past ten years at a single neurosurgical centre

Fowler H , Ghosh S , Buckler H , Heald A

Adults with brain tumours experience changes in multiple aspects of quality of life and this is associated with their medical condition and its treatment. There is some evidence to suggest that the mode of treatment is also a significant factor in the development of affective symptomatology. The primary aim is to explore within our cohort of patients treated for pituitary tumours, whether there are significant differences in multiple domains of quality of life and the severity...

ea0019oc26 | Bone and Calcium | SFEBES2009

Primary hyperparathyroidism (Nationwide Cohort Study): an increased risk of cancer and decreased survival

Ghosh S , Collier A , Clark D , Elhadd T , Malik I

Introduction: • The incidence of primary hyperparathyroidism (PHPT) in Scotland is approximately 3.5/100 000 per year.• The incidence is probably on the rise due to increase in ‘routine biochemical testing’• Some patients tend to undergo surgery, while others are conservatively treated and most followed up for a short period before discharge from follow up.Aims: • Determine if ri...

ea0007p188 | Reproduction | BES2004

Follow up of women with Turner's syndrome in an adult endocrine clinic

Ghosh S , Hussein N , Gibson C , Ray D , Wu F , Davis J

Turner's syndrome is the most commonly occurring chromosomal abnormality in females. Adults with Turner's have a threefold increase in mortality and life expectancy is reduced. Recent recommendations for the follow-up of women with Turner's syndrome include annual checks of thyroid function, serum lipids, blood glucose, liver function, renal function, and 3 to 5 yearly echocardiography, bone densitometry, and audiogram.We have reviewed actual follow-up m...

ea0009p119 | Endocrine tumours and neoplasia | BES2005

Comparison of long term psychological health in patients with treated Pituitary Cushing's and Nelson's syndrome vs. Adrenal Cushing's

Ghosh S , Heald A , Gibson C , Bray S , Anderson S , O'Driscoll K , Davis J , Buckler H , Fowler H

IntroductionWe have previously shown that patients with pituitary Cushing's have impaired quality of life vs. other pituitary tumour groups. Whether this is related to direct neural effects of excess ACTH or cortisol is uncertain. In order to address this, we compared patients who had undergone definitive treatment for pituitary vs adrenal Cushings.DesignWe assessed 14 patients with biochemically cured pituit...

ea0063oc10.1 | Adrenal 2 | ECE2019

Steroid metabolomics: a rapid computational approach for accurate differentiation of inborn disorders of steroidogenesis

Baranowski Elizabeth S , Ghosh Sreejita , Shackleton Cedric HL , Taylor Angela E , Hughes Beverly A , Gilligan Lorna C , Utari Agustini , Faradz Sultana MH , van Herwaarden Antonius E , Claahsen-van der Grinten Hedi L , Biehl Michael , Guran Tulay , Bunte Kerstin , Tino Peter , Arlt Wiebke

Background: Measurement of steroid metabolite excretion in urine by gas chromatography-mass spectrometry (GC-MS) provides a comprehensive profile of an individual’s adrenal and gonadal steroid production. It has long been acknowledged as a useful tool for diagnosis of inborn disorders of steroidogenesis leading to congenital adrenal hyperplasia and disorders of sex development. Ratios of steroid metabolites can be employed as surrogates for enzymatic activities of distinc...