Searchable abstracts of presentations at key conferences in endocrinology

ea0020oc2.5 | Diabetes & Obesity | ECE2009

Regular aerobic activity attenuates caspase-3 activity, oxidative stress, and progression of diabetic nephropathy in db/db mice, independent of hyperglycemia

Ghosh Sanjoy , Verchere Bruce , Laher Ismail

Diabetic nephropathy, the leading cause of end-stage renal disease, is characterized by a pro-apoptotic and pro-oxidative environment. The mechanisms by which lifestyle interventions, such as exercise, benefits diabetic nephropathy are unknown. We hypothesized that exercise inhibits early diabetic nephropathy via attenuation of the mitochondrial apoptotic pathway and oxidative damage. Type 2 diabetic db/db and normoglycemic wild type mice were exercised for an hour ever...