ea0063oc10.1 | Adrenal 2 | ECE2019
Baranowski Elizabeth S
, Ghosh Sreejita
, Shackleton Cedric HL
, Taylor Angela E
, Hughes Beverly A
, Gilligan Lorna C
, Utari Agustini
, Faradz Sultana MH
, van Herwaarden Antonius E
, Claahsen-van der Grinten Hedi L
, Biehl Michael
, Guran Tulay
, Bunte Kerstin
, Tino Peter
, Arlt Wiebke
Background: Measurement of steroid metabolite excretion in urine by gas chromatography-mass spectrometry (GC-MS) provides a comprehensive profile of an individuals adrenal and gonadal steroid production. It has long been acknowledged as a useful tool for diagnosis of inborn disorders of steroidogenesis leading to congenital adrenal hyperplasia and disorders of sex development. Ratios of steroid metabolites can be employed as surrogates for enzymatic activities of distinc...