Searchable abstracts of presentations at key conferences in endocrinology

ea0037s15.2 | Puberty: new mechanisms | ECE2015

GnRH development and function: lessons from semaphorins

Giacobini Paolo

This talk summarizes recent studies analysing the contribution of specific guidance molecules named semaphorins in the development and adult function of gonadotropin-releasing hormone (GnRH) neurons. In vertebrates, the GnRH decapeptide regulates the secretion of luteinizing hormone and follicle stimulating hormone, which govern puberty onset, gametogenesis, and estrous cycling, from anterior pituitary gonadotropes. During embryonic development, these cells originate from the ...

ea0056nsa4 | (1) | ECE2018

3D visualisation of the HPG axis in mice and humans

Giacobini Paolo

Histology has been a golden tool for biological research for decades. Nevertheless, whole organ histology is extremely time and resource consuming and most of the time impossible due to the distortions and lack of algorithms to correctly align thousands of sections. Light sheet-based microscopy is an important, innovative tool that offers nondestructive optical sectioning of selectively stained thick tissues at a spatial resolution between that of micro MRI and confocal micros...

ea0073s7.3 | Symposium 7: Inheritable metabolism | ECE2021

Transgenerational influences of AMH and the pathogenesis of PCOS

Giacobini Paolo

Polycystic ovary syndrome (PCOS) is the major reproductive and metabolic disorder affecting 10 - 15% of women in reproductive age. Up to 70 percent of daughters of women with PCOS also develop the disease, but genetic variation doesnÂ’t fully explain the high incidence within families and the mechanisms underpinning its transmission remain to be elucidated. We have previously shown that prenatal anti-Müllerian hormone (AMH) exposure leads to the manifestation of P...

ea0081oc12.3 | Oral Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Defective Notch1/Jag1 signaling impacts GnRH development and contributes to hypogonadotropic hypogonadism

Ludovica Cotellessa , Federica Marelli , Duminuco Paolo , Lucia Bartoloni , Michela Adamo , Pitteloud Nelly , Persani Luca , Bonomi Marco , Giacobini Paolo , Valeria Vezzoli

The precise development of the Gonadotropin Releasing Hormone (GnRH) neurons is essential for the proper function of the hypothalamic-pituitary-gonadal axis, as GnRH is the master regulator of reproductive functions in vertebrates. Mutations in genes involved in the development of GnRH neurons are associated with Congenital Hypogonadotropic Hypogonadism (CHH), a heterogeneous genetic disorder characterized by hypogonadism, lack of puberty onset, and infertility, which is named...

ea0081p700 | Reproductive and Developmental Endocrinology | ECE2022

Fetal exposure to anti-müllerian hormone triggers a transgenerational epigenetic transmission of polycystic ovary syndrome (PCOS) defects in adulthood

Nour El Houda Mimouni , Paiva Isabel , Barbotin Anne-Laure , Ezzahra Timzoura Fatima , Plassard Damien , Le Gras Stephanie , Ternier Gaetan , Pigny Pascal , Catteau-Jonard Sophie , Simon Virginie , Prevot Vincent , Boutillier Anne-Laurence , Giacobini Paolo

Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder affecting women in reproductive age. Women with PCOS exhibit 2-3x higher levels of circulating Anti-Müllerian Hormone (AMH) as compared to healthy women and it is unclear if the elevation of AMH is a bystander effect or is driving the condition. Moreover, PCOS has a strong heritable component, however the etiopathology of the disease and the mechanisms underlying its transmission remain t...

ea0081p182 | Reproductive and Developmental Endocrinology | ECE2022

Defining reference ranges for serum anti-Müllerian hormone (AMH) on a large cohort of normozoospermic adult men highlights new potential physiological functions of AMH on FSH secretion and sperm motility

Benderradji Hamza , Anne-Laure Barbotin , Maryse Leroy-Billiard , Julie Prasivoravong , Francois Marcelli , Christine Decanter , Geoffroy Robin , Valerie Mitchell , Jean-Marc Rigot , Antonino Bongiovanni , Florent Sauve , Luc Buee , Claude-Alain Maurage , Maryse Cartigny , Arnauld Villers , Vincent Prevot , Sophie Catteau-Jonard , Nicolas Sergeant , Paolo Giacobini , Pascal Pigny , Clara Leroy

Background: Few studies to date have attempted to measure serum anti-Müllerian hormone (AMH) levels in adult men, and solid references ranges have not yet been defined on a large cohort.Objective: In this study, we aimed to first establish the reference ranges for serum AMH and AMH-to-total testosterone ratio (AMH/tT) in adult males. Secondly, we investigated the relationship between serum AMH and both reproductive hormones and semen parameters....

ea0090oc7.1 | Oral Communications 7: Pituitary and Neuroendocrinology 2 | ECE2023

Investigating intranasal kisspeptin as a novel, effective and preferable route of delivery using human, rodent and pharmaceutical models

Mills Edouard G , Swedrowska Magda , Delli Virginia , Chachlaki Konstantina , Sergio Mauro , Decoster Laurine , Ternier Gaetan , Thurston Layla , Phylactou Maria , Patel Bijal , Yang Lisa , Clarke Sophie , Muzi Beatrice , Alexander Emma , Choudhury Muhammad , Bech Paul , Abbara Ali , Forbes Ben , Giacobini Paolo , Prevot Vincent , Comninos Alexander , Dhillo Waljit

Background: Kisspeptin is a critical activator of hypothalamic GnRH neurons and is essential for reproductive health. Emerging data reveals that kisspeptin-based therapeutics have substantial potential to treat reproductive, psychosexual and bone disorders. However, current delivery is limited to the subcutaneous or intravenous routes, presenting barriers to development. Alternative routes of administration would overcome this and capitalise on the benefits of kisspeptin-based...