Searchable abstracts of presentations at key conferences in endocrinology

ea0035p256 | Clinical case reports Pituitary/Adrenal | ECE2014

An unusual case of reversible empty sella

Triggiani Vincenzo , Giagulli Vito Angelo , Guastamacchia Edoardo

A 22-year-old female complaining about irregular menses associated to a slight increase of serum PRL and the recent onset of headache, nausea, dizziness, photophobia, occasional diplopia, visual impairment, anxiety and panic attacks was evaluated for the possible presence of a cerebral mass with intracranial hypertension. Fundoscopic examination and visual field were both normal. There was an empty sella with a flattened pituitary gland along the floor of the pituitary fossa a...

ea0041gp187 | Reproduction & Endocrine Disruption | ECE2016

Testosterone supplementation and body composition: results from a meta-analysis of observational studies

Corona Giovanni , Giagulli Vito A , Maseroli Elisa , Vignozzi Linda , Aversa Antonio , Zitzmann Michael , Saad Farid , Maggi Mario

Background: The concept of testosterone (T) supplementation (TS) as a new anti-obesity medication in men with testosterone deficiency syndrome (TDS) is emerging.Aim: To systematically review and meta-analyze available observational and register studies reporting data on body composition in studies on TS in TDS.Methods: An extensive Medline Embase and Cochrane search was performed including the following words: ‘testosterone&#1...

ea0041ep204 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Testosterone supplementation and body composition: results from a meta-analysis of randomized controlled trials

Corona Giovanni , Giagulli Vito A , Maseroli Elisa , Vignozzi Linda , Aversa Antonio , Zitzmann Michael , Saad Farid , Maggi Mario

Background: The role of testosterone (T) in regulating body composition is conflicting.Aim: To meta-analyze the effects of T supplementation (TS) on body composition and metabolic outcomes.Methods: All randomized controlled trials (RCTs) comparing the effect of TS on different endpoints were considered.Results: Overall, 59 trials were included in the study enrolling 3029 and 2049 patients in TS and control gr...

ea0032p1002 | Thyroid (non-cancer) | ECE2013

Diagnosis of hypothyroidism is associated to an increased risk of acute decompensated heart failure occurrence, but not of mortality among heart failure outpatients

Triggiani Vincenzo , Iacoviello Massimo , Puzzovivo Agata , Antoncecchi Valeria , Angelo Giagulli Vito , Guastamacchia Edoardo , Favale Stefano

It has been demonstrated that hypothryoidism could affect the prognosis of patients with cardiovascular disease. The aim of this study was to better clarify the prognostic role of hypothyroidism in patients with chronic heart failure (CHF).We enrolled 384 consecutive outpatients (65±13 years, 296 males, NYHA 2.3±0.6, left ventricular ejection fraction, LVEF, 32±9%) with CHF (ESC criteria), in stable clinical conditions (at least 30 days) a...

ea0081p355 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

GLP-1 receptor agonists and erectile dysfunction in diabetic men with and without hypogonadism: a 1- year retrospective observational study

Lisco Giuseppe , Isabella Ramunni Maria , De Pergola Giovanni , Jirillo Emilio , Guastamacchia Edoardo , Triggiani Vincenzo , Angelo Giagulli Vito

Background: Erectile dysfunction affects nearly half of men with type 2 diabetes (T2DM), and one-third of diabetic men have hypogonadism1. As an add-on to TRT in hypogonadal men with T2DM, Liraglutide may improve erectile function2, and dulaglutide decreased the incidence of moderate and severe ED in T2DM3.Study aims: To assess the GLP-1RA effect in T2DM men complaining of ED treated with both liraglutide and dulaglutide ...

ea0090p209 | Thyroid | ECE2023

The TNAPP web-based algorithm improves thyroid nodule management in clinical practice. A retrospective validation study

Lisco Giuseppe , Renzulli Giuseppina , Frasoldati Andrea , Guglielmi Rinaldo , Angelo Giagulli Vito , Guastamacchia Edoardo , R Garber Jeffrey , Triggiani Vincenzo , Papini Enrico

The detection of thyroid nodules has been increasing over time, resulting in an extensive use of fine-needle aspiration (FNA) and cytology. Tailored methods are required to improve the management of thyroid nodules, including algorithms and web-based tools. To assess the performance of the Thyroid Nodule App (TNAPP), a web-based, interactive algorithmic tool, in improving the management of thyroid nodules, we carried out a preliminary analysis on a cohort of outpatients. One h...

ea0041oc10.5 | Reproduction & Endocrine Disruption | ECE2016

Effect of clomiphene citrate and metformin on testosterone levels in hypogonadal obese men with impaired glucose tolerance (IGT) or type 2 diabetes (DM2)

Pelusi Carla , Giagulli Vito , Baccini Margherita , Fanelli Flaminia , Mezzullo Marco , Fazzini Alessia , Casadio Elena , Prontera Olga , Pagotto Uberto , Pasquali Renato

Low testosterone (T) levels are often found in obese men with metabolic abnormalities, however the mechanism underling this condition is unclear. This study aimed to evaluate the effectiveness of clomiphene citrate (CC) in increasing T levels and improving metabolic control in hypogonadal obese men with IGT or DM2. A randomized cross-over double blind controlled study was conducted in twenty obese hypogonadal caucasian men, mean age 47 ys, classified in IGT (n=11) or ...

ea0037ep629 | Obesity and cardiovascular endocrinology | ECE2015

IGF-1 levels correlate with T3 status in chronic heart failure outpatients: preliminary data

Triggiani Vincenzo , Iacoviello Massimo , Leone Marta , Giagulli Vito Angelo , Guastamacchia Edoardo , Salzano Andrea , Bobbio Emanuele , Arcopinto Michele , Cittadini Antonio

Background: A variety of hormones may be down-regulated in CHF patients. Impaired activity of the GH/IGF-1 axis has been described and is associated with poor clinical status and outcome. Moreover, a decrease in serum T3 is correlated to the severity of the heart disease as assessed by the NYHA classification. Aim of this study was to evaluate a possible correlation between IGF-1 levels and T3 status in a cohort of CHF outpatients.M...

ea0081p309 | Calcium and Bone | ECE2022

Testosterone supplementation and bone parameters, a systematic review and meta-analysis study

Vena Walter , Corona Giovanni , Pizzocaro Alessandro , Giagulli Vito , Francomano Davide , Rastrelli Giulia , Aversa Antonio , Marcello Isidori Andrea , Pivonello Rosario , Vignozzi Linda , Mannucci Edoardo , Maggi Mario , Ferlin Alberto

Background: Testosterone (T) is essential for bone health during all ages, helping to achieve a proper peak bone mass and, later, to maintain bone density and strength. Guidelines on management of male osteoporosis recommend testosterone replacement in young-adult hypogonadal to prevent bone loss and anti-resorbitive drugs in case of high fracture risk, but the role of T replacement therapy (TRT) alone in subjects with late onset hypogonadism is still the object of an intense ...

ea0090p61 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

The dual GIP/GLP-1 receptor co-agonist Tirzepatide vs GLP-1 receptor agonists as add-on to basal insulin in uncontrolled type 2 diabetes mellitus: A rapid review of randomized controlled trials and meta-analysis

Lisco Giuseppe , De Tullio Anna , Disoteo Olga , De Geronimo Vincenzo , Piazzolla Giuseppina , De Pergola Giovanni , Angelo Giagulli Vito , Jirillo Emilio , Guastamacchia Edoardo , Sabba Carlo , Triggiani Vincenzo

Tirzepatide, a once-weekly dual co-agonist of Glucose-Dependent Insulinotropic Polypeptide (GIP) and Glucagon-Like Peptide 1 (GLP-1) receptors, has been demonstrated to improve glucose control and reduced body weight in different therapeutic approaches. With this rapid review and meta-analysis, we systematically reviewed the efficacy and safety of injectable incretin-based therapy added to basal insulin compared to basal insulin plus background treatments titrated rigorously t...