Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep1004 | Hot topics (including COVID-19) | ECE2020

Impact of covid-19 pandemic on psychophysical stress in patients with adrenal insufficiency: The corti-covid study

Martino Marianna , Aboud Nairus , Fabio Cola Marco , Giancola Giulia , Ciarloni Alessandro , Salvio Gianmaria , Arnaldi Giorgio

Background: COVID-19 pandemic is a novel, potentially adverse condition for patients with adrenal insufficiency (AI), whose life expectancy and quality of life (QoL) are impaired due to their risk of infections and stress-triggered acute events. Therapeutic usefulness of glucocorticoids in COVID-19 is debated, but infected AI patients require prompt replacement tailoring.Objectives: In a cohort of AI patients, to assess:– the...

ea0081p22 | Adrenal and Cardiovascular Endocrinology | ECE2022

Mesenchymal Stem Cells exposed to persistently high glucocorticoid levels develop insulin-resistance and altered lipolysis: a promising in vitro model to study Cushing’s Syndrome

Di Vincenzo Mariangela , Martino Marianna , Lariccia Vincenzo , Giancola Giulia , Licini Caterina , Di Benedetto Giovanni Maria , Orciani Monia , Arnaldi Giorgio

Objective: In Cushing’s Syndrome, chronic glucocorticoid excess and their disrupted circadian rhythm lead to insulin-resistance, diabetes mellitus, dyslipidemia and cardiovascular comorbidities. As undifferentiated, self-renewing progenitors of adipocytes, mesenchymal stem cells may display the detrimental effects of glucocorticoid excess, thus revealing a promising model to study molecular mechanisms underlying metabolic complications of Cushing’s Syndrome.<p cl...

ea0081p412 | Pituitary and Neuroendocrinology | ECE2022

Sodium alterations impair the long-term prognosis of hospitalized patients with COVID-19 pneumonia: hospital readmissions and mortality rates after a 18-month follow-up

Martino Marianna , Aboud Nairus , Perrone Michele , Falcioni Paolo , Giancola Giulia , Ciarloni Alessandro , Salvio Gianmaria , Silvetti Francesca , Taccaliti Augusto , Arnaldi Giorgio

Background: Dysnatremia is common in hospitalized patients, often worsening the prognosis in pneumopathies and critical illnesses, such as COVID-19. Here, hyponatremia is an indicator of pulmonary involvement, while hypernatremia is associated with worse assistance outcomes, particularly when resulting from an overcorrected hyponatremia. Longer hospitalizations, readmissions after discharge and higher short- and long-term mortality rates have been observed in acute patients ex...