Searchable abstracts of presentations at key conferences in endocrinology

ea0016oc1.7 | Neuroendocrinology and pituitary | ECE2008

Intermittent high glucose concentrations reduce neuronal precursor proliferation by altering the IGF system: the involvement of the neuroprotective factor seladin-1

Giannini Stefano , Pezzatini Anna , Luciani Paola , Manuelli Cinzia , Benvenuti Susanna , Cellai Ilaria , Deledda Cristiana , Vannelli Gabriella Barbara , Rotella Carlo Maria , Serio Mario , Peri Alessandro

The exposure of cells to high glucose concentrations is considered a determinant of diabetic neuropathy. Conversely, members of the Insulin-like Growth Factor (IGF) system are well known neurotrophic factors. Here, we investigated the effects of constant and intermittent high glucose concentrations on IGF-I and IGF Binding Proteins (IGFBPs) in human neuroblast long-term cell cultures (FNC). We first demonstrated that FNC express the IGF-I receptor, and express and release in t...