Searchable abstracts of presentations at key conferences in endocrinology

ea0019p258 | Pituitary | SFEBES2009

Growth hormone replacement and its effect on muscle strength in GH-deficient adults: a meta-analysis

Widdowson WM , Gibney J

A recently published meta-analysis has demonstrated a significant beneficial effect on exercise performance of growth hormone (GH) replacement in GH-deficient (GHD) adults. The current meta-analysis was carried out to determine whether GH replacement confers a similar improvement in muscle strength in this patient group. A medline search and examination of reference lists of included studies and relevant review articles identified five studies with utilizable, robust data, inv...

ea0055wc4 | Workshop C: Disorders of the thyroid gland (I) | SFEEU2018

A common case of goitre, thyroid nodules and thyroid carcinoma

Tansey Dr David J , Gibney Dr James

A 31 year-old woman is referred into the Endocrine clinic with a palpable mass in her right anterior neck that was found incidentally by her GP. She had no known past medical history, did not take any medications and had not noticed any dysphagia, neck pain, or compressive symptoms. On clinical exam, there was an enlarged thyroid with a 1.5-cm left-sided thyroid nodule that moved on swallowing. There was no palpable cervical lymphadenopathy. TSH was 2.5 mIU/l (0.29–5.1 mI...

ea0059ep97 | Thyroid | SFEBES2018

The Use of Salvage Radiotherapy and Radioactive Iodine in a Case of Recurrent Metastatic Papillary Thyroid Cancer: A Case Report

Tansey David J , Gibney James , Salib Osama

Background: Thyroid carcinoma consists of just 1% of all malignancies but is the commonest malignant endocrine tumour. Papillary thyroid carcinoma is the most common form of thyroid carcinoma consisting of 80% of all cases. There are very few case reports in the literature of papillary thyroid cancers presenting with distant to the pelvic organs. Distant metastases are noted in 1–3% of patients with thyroid cancer at initial diagnosis.Clinical case:...

ea0029p1562 | Thyroid (non-cancer) | ICEECE2012

Hypothyroidism is associated with increased intestinally derived lipoprotein particles and postprandial endothelial dysfunction

McGowan A. , Widdowson W. , Boran G. , Gibney J.

Atheroma is accelerated in overt hypothyroidism (OH) and possibly in subclinical-hypothyroidism (SCH), and is not completely explained by increased LDL-cholesterol. There is little data available regarding post-prandial metabolic changes in OH or SCH.Subjects with OH (n=21), SCH (n=28) and age, sex and BMI matched controls (n=50) were studied fasting and for up to 8-h following a mixed-meal. Investigations included apolipoprotein(apo...

ea0007p178 | Reproduction | BES2004

Routine screening for macroprolactin

Gibney J , Smith T , McKenna T

Macroprolactin has reduced bioactivity and accumulates in the sera of some subjects, resulting in apparent hyperprolactinaemia. Development of the polyethyleneglycol (PEG) precipitation technique has enabled large-scale screening for macroprolactin in hyperprolactinaemic subjects. We have reviewed the experience of routine screening for macroprolactin using PEG precipitation over a 54-month period in a single centre.Plasma levels of prolactin exceeded 50...

ea0007p236 | Thyroid | BES2004

Hypothyroidism is less frequent following radioactive iodine treatment for toxic nodular goitre than Graves' disease

Adamali H , Gibney J , McKenna T

Since the thyroid is diffusely active in Graves' disease (GD) but exhibits focal activity in toxic nodular goitre (TNG), we tested the hypothesis that hypothyroidism will occur more frequently following radioactive iodine treatment (RAI), in patients with GD compared to those with TNG. To do this we reviewed the outcome of treatment in 86 patients, age 49.7 plus/minus 1.5 years (mean plus/minus SEM), with GD, and 77 patients, age 62.7 plus/minus 1.3 years, with TNG, followed o...

ea0049ep572 | Diabetes complications | ECE2017

The prevalence of chronic kidney disease and albuminuria in patients with Type 1 and Type 2 diabetes attending a single centre

Majeed MS , Boran G , Behan LA , Sherlock M , Gibney J

Chronic kidney disease (CKD) is an important complication of diabetes and determinant of mortality. Albuminuria represents early diabetic nephropathy, and also indicates generalised vascular dysfunction. Understanding the epidemiology of CKD and albuminuria helps inform health planning and identify opportunities to prevent or delay progression of diabetic kidney disease. The last available serum creatinine and urine albumin/creatinine ratio (UACR) in patients with Type 1 (T1DM...

ea0007p8 | Bone | BES2004

Application of new indices of bone activity for evaluation of the response to treatment of hyperthyroidism and Paget's disease

Smith D , Murray B , Gibney J , O'Shea D , McKenna T

While it is generally acknowledged that hyperthyroidism and Paget's disease are states of increased bone turnover and that treatment reduces this, whether treatment entirely corrects or reverses abnormalities has not been established. A variety of biomarkers for bone formation which include serum levels of bone alkaline phosphatase (BAP), osteocalcin (OC) and amino terminal procollagen type 1N propeptide (PINP) and resorption biomarkers which include urinary excretion of deoxy...

ea0005p203 | Reproduction | BES2003

A more rigorous laboratory definition of macroprolactinaemia with clinical significance

Smith T , Gibney J , Kavanagh L , Dickinson A , McKenna T

The importance of the differentiation between the apparent benign clinical condition of macroprolactinaemia and that of true hyperprolactinaemia, which requires therapy, is becoming widely recognised. Laboratories routinely rely on prolactin recoveries of less than 40 percent following treatment of sera with polyethylene glycol (PEG) to distinguish between the former and latter conditions. However, the 40 percent threshold employed is arbitrarily defined with little scientific...

ea0049ep70 | Adrenal cortex (to include Cushing's) | ECE2017

Abnormal aldosterone/renin ratio is common in patients of African compared to European origin, is associated with hypokalaemia, and left ventricular hypertrophy, but is rarely associated with abnormal adrenal imaging characteristics

Ahmed KS , Bogdanet D , Heshe S , Boran G , Behan LA , Sherlock M , Gibney J

Adrenal mineralocorticoid biochemistry differs between people of African and European ancestry. The aldosterone/renin ratio (ARR) is the initial screening test for primary hyperaldosteronism (PHA), but little data exists regarding ethnic variations in this.Following clinical observation of a high prevalence of abnormal ARR in patients of African origin, we retrospectively reviewed all ARR measurements in a single centre over 10 years. Rates of hypokalaem...