Searchable abstracts of presentations at key conferences in endocrinology

ea0016p533 | Obesity | ECE2008

Pentraxin 3 production in human visceral adipose tissue is associated with cardiovascular risk factors

Alberti Luisella , Gilardini Luisa , Girola Andrea , Micheletto Giancarlo , Peri Giuseppe , Doni Andrea , Mantovani Alberto , Invitti Cecilia

Pentraxin 3 (PTX3) is an acute phase protein expressed in the advanced atherosclerotic lesions and produced by endothelial cells, macrophages and, in rodents also by adipocytes under tumour necrosis factor α (TNFα) exposure. We investigated if PTX3 is expressed in human adipose tissue and is associated with cardiometabolic risk factors.Methods: Samples of subcutaneous (SAT) and omental visceral (VAT) adipose tissue were obtained from 21 obese (...

ea0014p200 | (1) | ECE2007

Expression of PKA regulatory subunits inversely correlates with BMI and insulin resistance parameters in human adipocytes from lean and obese subjects

Bondioni Sara , Mantovani Giovanna , Alberti Luisella , Corbetta Sabrina , Gilardini Luisa , Invitti Cecilia , Zappa Marco Antonio , Ferrero Stefano , Peverelli Erika , Lania Andrea G , Beck-Peccoz Paolo , Spada Anna

In human adipocytes the cAMP-dependent pathway mediates signals originating from the activation of beta-adrenergic receptors, thus playing a key role in the regulation of important metabolic processes such as lipolysis and thermogenesis. CyclicAMP effects are mainly mediated by cAMP-dependent protein kinase (PKA), a tetrameric enzyme composed by two catalytic subunits associated with two regulatory (R) subunits. There are four different R subunit genes and proteins (R1A, R1B, ...