ea0009p133 | Steroids | BES2005
Le Rouzic P
, Gillingham H
, Berry A
, Garside H
, White A
, Ray D
Glucocorticoid sensitivity is dependent on the intracellular concentration of the glucocorticoid receptor (GR). GR expression is regulated in a complex, cell-type specific manner, but in most cell types the GR is subject to negative autoregulation by glucocorticoid exposure. Many human diseases are associated with reduced tissue sensitivity to glucocorticoids, including inflammatory arthritis, asthma, and chronic obstructive pulmonary disease. Therefore there is interest in ap...