Searchable abstracts of presentations at key conferences in endocrinology

ea0035s1.1 | Endocrine changes and treatment needs in critically ill patients | ECE2014

Thyroid dysfunction in critically ill patients: to treat or not to treat?

Iervasi Giorgio

The low-triiodothyronine (T3) syndrome, also referred as non thyroidal illness, is a frequent finding usually associated to a wide constellation of both acute and chronic extra-thyroid critical disorders that largely differ each other in terms of aetiology, organ involvement, evolution, and clinical impact. Independently of its origin, severity and time-course, the low-T3 syndrome has been always considered an adaptive and positive process not needing spe...

ea0032p1100 | Thyroid cancer | ECE2013

Thyroglobulin in fine-needle aspiration wash-out diagnostic performance: a meta-analysis

Grani Giorgio , Fumarola Angela

Introduction: Differentiated thyroid cancer (DTC) has an excellent prognosis. However, DTC frequently metastasizes to cervical lymph nodes (CLN). In case of suspicious ultrasonography findings, the fine-needle aspiration (FNA) is usually required to confirm or exclude metastasis. The combination of FNA-cytology and thyroglobulin (Tg) measurements in the needle washout has been reported to increase the sensitivity of FNA in identifying lymph node metastases from DTC, particular...

ea0081oc3.3 | Oral Communications 3: Thyroid 1 | ECE2022

Adata-driven approach reveals emerging risk factors for recurrent and persistent differentiated thyroid cancer

Gentili Michele , Grani Giorgio , Siciliano Federico

Background: The appropriate risk stratification of patients with differentiated thyroid cancer (DTC) is crucial because most cases have an indolent behavior and need a conservative approach. One of the most widely used tools is included in the American Thyroid Association (ATA) Guidelines, based on heterogeneous literature data derived by different populations, settings, and timeframes. Recent research focused on the inclusion of other features or questioned the clinical relev...

ea0022p578 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Use of the desmopressin test in the differential diagnosis of Pseudo-Cushing state from Cushing's disease

Tirabassi Giacomo , Faloia Emanuela , Papa Roberta , Furlani Giorgio , Boscaro Marco , Arnaldi Giorgio

Context: The desmopressin (DDAVP) test has been proposed to discriminate CushingÂ’s disease (CD) from Pseudo-Cushing states (PC); however, current information on its value is scarce and contradictory.Objective: To assess the ability of the DDAVP test in distinguishing between these conditions, with emphasis on subjects with mild hypercortisolism.Design: Retrospective/prospective study.Setting: Division of...

ea0020p580 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Human corticotropin releasing hormone (hCRH) test performance in the differential diagnosis between Cushing's disease and pseudo-Cushing state is enhanced by combined ACTH and cortisol analysis

Tirabassi Giacomo , Arnaldi Giorgio , Papa Roberta , Furlani Giorgio , Trementino Laura , Cardinaletti Marina , Faloia Emanuela , Boscaro Marco

Objective: The corticotropin releasing hormone (CRH) test does not reliably distinguish between CushingÂ’s disease (CD) and normality or pseudo-Cushing state (PC). In this study we assessed whether the application of novel criteria could enhance its diagnostic performance.Design: Retrospective study.Patients: Fifty-one subjects with CD, 26 with PC and 31 control subjects (CT).Measurements: All subjects un...

ea0070aep25 | Adrenal and Cardiovascular Endocrinology | ECE2020

The glucocorticoid receptor in macrophages protects against inulin resistance and promotes homeothermy

Caratti Giorgio , Stifel Ulrich , Kozak Bozhena , Rauch Alexander , Tuckermann Jan

Insulin resistance and obesity are a global health problem and directly linked to macrophage-driven inflammation of the adipose tissue. Glucocorticoid therapy, used to treat inflammatory conditions, increases adiposity and insulin resistance. It is unknown however, whether anti-inflammatory actions of glucocorticoids at physiological levels can have beneficial effects on adipose tissue inflammation, potentially limiting insulin resistance. Using a macrophage specific deletion ...

ea0073aep637 | Thyroid | ECE2021

Persistently elevated procalcitonin levels in Covid-19 pneumoniae leading to medullary thyroid cancer diagnosis

Gianotti Laura , Salvatore D’Agnano , Tassone Francesco , Pettiti Giorgio , Lauria Giuseppe , Del Bono Valerio , Borretta Giorgio

ObjectiveWe report a case of acute respiratory syndrome coronavirus 2 (SARSCoV2) pneumonia in which persistently high procalcitonin (PCT) allowed the diagnosis of sporadic medullary thyroid cancer (MTC).MethodsWe describe the history of 43-year-old male with bilateral Sars-Cov-2 pneumoniae, in whom persistent increased PCT despite reduction of C reactive protein lead to investigate other causes of high PCT. S...

ea0081yi4 | Young Investigator Awards | ECE2022

The role of miR-335-5p in the differentiation of thyroid cancers with BRAF mutation

Pecce Valeria , Verrienti Antonella , Sponziello Marialuisa , Grani Giorgio , Bini Simone , Filetti Sebastiano , Durante Cosimo

The most frequent mutation in papillary thyroid carcinoma (PTC) is the p.V600E of the BRAF gene. This mutation leads to the aberrant activation of the RAS / BRAF / MEK / ERK pathway and consequently to the under-regulation of thyroid-specific genes, resulting in uncontrolled growth and de-differentiation of cancer cells. In this work, we analyzed the transcriptomics data produced by the TCGA project using a network approach. The analysis led to the identification of r...

ea0081ep164 | Calcium and Bone | ECE2022

The clinical presentation of primary hyperparathyroidism during the Covid-19 pandemic

Castellano Elena , Borretta Giorgio , Pellegrino Micaela , Tassone Francesco , Craparo Andrea , Baffoni Claudia , Gianotti Laura

Background: In the last decades, the clinical profile of PHPT in Western Countries has changed from a highly symptomatic to a largely asymptomatic disease. However, a substantial stability in its clinical features has been reported in the last two decades. The usual management, including time to diagnosis and treatment, of PHPT during the Covid-19 pandemic has been changed and likely slowed down. Whether further changes in the clinical presentation of PHPT have occurred during...

ea0081ep304 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Empagliflozin and arterial stiffness in type 2 diabetic patients: a real clinical practice case-control study

Tassone Francesco , Ferreri Cinzia , Rossi Arianna , Baffoni Claudia , Borretta Giorgio , Feola Mauro

Background: Sodium-glucose cotransporter-2 (SGLT2) inhibitors demonstrated beneficial effects on cardiovascular and renal events in patients with type 2 diabetes mellitus. The mechanisms underlying these effects are not fully elucidated. Aim of this study was to investigate whether empagliflozin is able to affect arterial stiffness/pulse wave velocity in type 2 diabetic patients.Methods: Pulse wave velocity and other parameters of arterial stiffness were...