Endocrine Abstracts

Acromegaly (A) is associated with the bone overgrowth and soft tissue abnormalities due to anabolic, lipolytic and sodium retaining actions of GH.Aim: To investigate the effects of medical treatment on bone mineral density (BMD) of proximal femur, lumbar spine and tissue distribution. We observed 56 patients (14 M and 42 F) with A. BMD was measured using dual-energy X-ray absorptiometry with ‘total body’ program. The patients were treated with ...

Occurrence of arterial hypertension (AH) in acromegaly (A) is the significant risk factor for sudden death. The study group included 232 patients with A aged 47–67 year (mean age 54). The duration of active phase of A was 7–17 years (median 11), GH levels were 23–19.2 ng/ml (mean 6.5), IGF-1 were 223–568 ng/ml (mean 354). AH was found in 186 patients (80.2%): 1st degree – 27%, 2nd – 32%, 3rd – 41%. Of 24-hour arterial blood pressure monitorin...